loading...| Preferred Name |
Dirithromycin |
|
| Synonyms |
DIRITHROMYCIN Dirithromycin Erythromycin, 9-deoxo-11-deoxy-9,11-(imino(2-(2-methoxyethoxy)ethylidene)oxy)-,(9S(R))- Dynabac |
|
| Definitions |
A semi-synthetic macrolide antibiotic pro-drug. Dirithromycin is converted by hydrolysis during intestinal absorption into the microbiologically active erythromycylamine. Eryhtromylamine binds to the 50 S subunit of the 70 S ribosome of susceptible organisms, thereby inhibiting bacterial RNA-dependent protein synthesis. This antibiotic is used in the treatment of infections of the respiratory tract, skin and soft tissue caused by gram-positive microorganisms, including S. aureus, S. pneumonia and pyogenes, gram-negative microorganisms, including H. influenzae, L. pneumophila, M. catarrhalis, and M. pneumoniae. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47496 |
|
| CAS_Registry |
62013-04-1 |
|
| CHEBI_ID |
CHEBI:474014 |
|
| Chemical_Formula |
C42H78N2O14 |
|
| code |
C47496 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
A semi-synthetic macrolide antibiotic pro-drug. Dirithromycin is converted by hydrolysis during intestinal absorption into the microbiologically active erythromycylamine. Eryhtromylamine binds to the 50 S subunit of the 70 S ribosome of susceptible organisms, thereby inhibiting bacterial RNA-dependent protein synthesis. This antibiotic is used in the treatment of infections of the respiratory tract, skin and soft tissue caused by gram-positive microorganisms, including S. aureus, S. pneumonia and pyogenes, gram-negative microorganisms, including H. influenzae, L. pneumophila, M. catarrhalis, and M. pneumoniae. |
|
| FDA_UNII_Code |
1801D76STL |
|
| FULL_SYN |
DIRITHROMYCIN Dirithromycin Erythromycin, 9-deoxo-11-deoxy-9,11-(imino(2-(2-methoxyethoxy)ethylidene)oxy)-,(9S(R))- Dynabac |
|
| label |
Dirithromycin |
|
| Legacy Concept Name |
Dirithromycin |
|
| Preferred_Name |
Dirithromycin |
|
| prefixIRI |
Thesaurus:C47496 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C0058445 |
|
| subClassOf |