National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Preferred Name

Therapeutic Epinephrine
Synonyms

EPINEPHRINE

Epinephrine

Therapeutic Epinephrine

Epinephrine autoinjector

Adrenal

Adrenaline

Epi

Epipen

adrenaline
Definitions

The synthetic form of the naturally occurring sympathomimetic amine with vasoconstricting, intraocular pressure-reducing, and bronchodilating activities. By stimulating vascular alpha-adrenergic receptors, epinephrine causes vasoconstriction, thereby increasing vascular resistance and blood pressure. When administered in the conjunctiva, this agent binds to alpha-adrenergic receptors in the iris sphincter muscle, resulting in vasoconstriction, a decrease in the production of aqueous humor, and a lowering of intraocular pressure. Through its beta1 receptor-stimulating actions, epinephrine increases the force and rate of myocardial contraction and relaxes bronchial smooth muscle, resulting in bronchodilation.
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C473
ALT_DEFINITION

Epinephrine is a sympathomimetic drug that increases blood pressure and enhances ventricular contractility.
CAS_Registry

51-43-4
CHEBI_ID

CHEBI:28918
Chemical_Formula

C9H13NO3
code

C473
Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191406

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191200

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191387

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191671

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923
Contributing_Source

ACC/AHA

CTRP

FDA

HemOnc
DEFINITION

The synthetic form of the naturally occurring sympathomimetic amine with vasoconstricting, intraocular pressure-reducing, and bronchodilating activities. By stimulating vascular alpha-adrenergic receptors, epinephrine causes vasoconstriction, thereby increasing vascular resistance and blood pressure. When administered in the conjunctiva, this agent binds to alpha-adrenergic receptors in the iris sphincter muscle, resulting in vasoconstriction, a decrease in the production of aqueous humor, and a lowering of intraocular pressure. Through its beta1 receptor-stimulating actions, epinephrine increases the force and rate of myocardial contraction and relaxes bronchial smooth muscle, resulting in bronchodilation.
Display_Name

Therapeutic Epinephrine
FDA_UNII_Code

YKH834O4BH
FULL_SYN

EPINEPHRINE

Epinephrine

Therapeutic Epinephrine

Epinephrine autoinjector

Adrenal

Adrenaline

Epi

Epipen

adrenaline
Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C74941

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C48021
label

Therapeutic Epinephrine
Legacy Concept Name

Therapeutic_Epinephrine
NCI_Drug_Dictionary_ID

41857
NSC Number

62786
PDQ_Closed_Trial_Search_ID

41857
PDQ_Open_Trial_Search_ID

41857
Preferred_Name

Therapeutic Epinephrine
prefixIRI

Thesaurus:C473
Semantic_Type

Organic Chemical

Pharmacologic Substance
UMLS_CUI

C0014563
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C126567

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C87053
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