National Cancer Institute Thesaurus

Last uploaded: September 30, 2019
Preferred Name

Dacarbazine

Synonyms

Imidazole Carboxamide Dimethyltriazeno

4-(Dimethyltriazeno)imidazole-5-carboxamide

dacarbazine

Asercit

Dimethyl Triazeno Imidazole Carboxamide

5(or 4)-(dimethyltriazeno)imidazole-4(or 5)-carboxamide

Deticene

5-(Dimethyltriazeno)imidazole-4-carboxamide

Dacarbazine

Dakarbazin

dimethyl-triazeno-imidazole carboxamide

Biocarbazine

Dimethyl-triazeno-imidazole-carboximide

Dacarbazina

DTIC-Dome

Dimethyl Triazeno Imidazol Carboxamide

DIC

Dacatic

Dacarbazine - DTIC

5-(dimethyltriazeno)imidazole-4-carboxamide

DACARBAZINE

Imidazole carboxamide

Dimethyl (triazeno) imidazolecarboxamide

1H-imidazole-4-carboxamide, 5-(3,3-dimethyl-1-triazenyl)-

Dacarbazina Almirall

DTIC

WR-139007

Fauldetic

Imidazole Carboxamide

5-(3-3-dimethyl-1-triazenyl)-1H-imidazole-4-carboxamide

Detimedac

Definitions

A triazene derivative with antineoplastic activity. Dacarbazine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. (NCI04)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C411

Accepted_Therapeutic_Use_For

Carcinoid cancer; Hodgkins disease; Islet cell carcinoma; Melanoma; Neuroblastoma; Soft tissue sarcoma

ALT_DEFINITION

A drug that is used to treat Hodgkin lymphoma and malignant melanoma and is being studied in the treatment of other types of cancer. It attaches to DNA in cells and may kill cancer cells. It is a type of alkylating agent.

CAS_Registry

4342-03-4

CHEBI_ID

CHEBI:4305

Chemical_Formula

C6H10N6O

code

C411

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

A triazene derivative with antineoplastic activity. Dacarbazine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. (NCI04)

Display_Name

Dacarbazine

FDA_UNII_Code

7GR28W0FJI

FULL_SYN

Imidazole Carboxamide Dimethyltriazeno

4-(Dimethyltriazeno)imidazole-5-carboxamide

dacarbazine

Asercit

Dimethyl Triazeno Imidazole Carboxamide

5(or 4)-(dimethyltriazeno)imidazole-4(or 5)-carboxamide

Deticene

5-(Dimethyltriazeno)imidazole-4-carboxamide

Dacarbazine

Dakarbazin

dimethyl-triazeno-imidazole carboxamide

Biocarbazine

Dimethyl-triazeno-imidazole-carboximide

Dacarbazina

DTIC-Dome

Dimethyl Triazeno Imidazol Carboxamide

DIC

Dacatic

Dacarbazine - DTIC

5-(dimethyltriazeno)imidazole-4-carboxamide

DACARBAZINE

Imidazole carboxamide

Dimethyl (triazeno) imidazolecarboxamide

1H-imidazole-4-carboxamide, 5-(3,3-dimethyl-1-triazenyl)-

Dacarbazina Almirall

DTIC

WR-139007

Fauldetic

Imidazole Carboxamide

5-(3-3-dimethyl-1-triazenyl)-1H-imidazole-4-carboxamide

Detimedac

label

Dacarbazine

Legacy_Concept_Name

Dacarbazine

NSC_Code

45388

PDQ_Closed_Trial_Search_ID

39768

PDQ_Open_Trial_Search_ID

39768

Preferred_Name

Dacarbazine

prefixIRI

ncit:C411

Semantic_Type

Pharmacologic Substance

Organic Chemical

UMLS_CUI

C0010927

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C902

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http://phenomebrowser.net/ontologies/mesh/mesh.owl#D003606 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.129.308.240 RH-MESH LOOM
http://purl.bioontology.org/ontology/VANDF/4018386 VANDF LOOM
http://purl.obolibrary.org/obo/CHEBI_4305 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_4305 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_4305 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_4305 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_4305 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_4305 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_4305 NIFSTD LOOM
http://purl.bioontology.org/ontology/SNMI/C-78090 SNMI LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#3597 OCHV LOOM
http://purl.jp/bio/4/id/200906004842005622 IOBC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387441003 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/MESH/D003606 MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.925.200 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146713 NDFRT LOOM
http://stirdf.jst.go.jp/id/200907031160358150 IOBC LOOM
http://purl.bioontology.org/ontology/NDDF/002671 NDDF LOOM
http://purl.bioontology.org/ontology/RCD/h54.. RCD LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000039768 PDQ LOOM
http://purl.bioontology.org/ontology/UATC/L01AX04 ATC LOOM
http://purl.bioontology.org/ontology/RXNORM/3098 RXNORM LOOM
http://www.drugbank.ca/drugs/DB00851 FTC LOOM
http://www.co-ode.org/ontologies/galen#Dacarbazine GALEN LOOM
http://purl.bioontology.org/ontology/CSP/1548-5525 CRISP LOOM