National Cancer Institute Thesaurus

Last uploaded: September 30, 2019
Preferred Name

Moxifloxacin Hydrochloride

Synonyms

Moxeza

Vigamox

MOXIFLOXACIN HYDROCHLORIDE

Avelox

BAY 128039

Moxifloxacin Hydrochloride

Definitions

The hydrochloride salt of a fluoroquinolone antibacterial antibiotic. Moxifloxacin binds to and inhibits the bacterial enzymes DNA gyrase (topoisomerase II) and topoisomerase IV, resulting in inhibition of DNA replication and repair and cell death in sensitive bacterial species.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38696

Accepted_Therapeutic_Use_For

Various bacterial infections; Bacterial Conjunctivitis

ALT_DEFINITION

A drug used to treat bacterial infections. It is a type of fluoroquinolone.

CAS_Registry

186826-86-8

CHEBI_ID

CHEBI:7008

Chemical_Formula

C21H24FN3O4.HCl

code

C38696

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

The hydrochloride salt of a fluoroquinolone antibacterial antibiotic. Moxifloxacin binds to and inhibits the bacterial enzymes DNA gyrase (topoisomerase II) and topoisomerase IV, resulting in inhibition of DNA replication and repair and cell death in sensitive bacterial species.

Display_Name

Moxifloxacin Hydrochloride

FDA_UNII_Code

C53598599T

FULL_SYN

Moxeza

Vigamox

MOXIFLOXACIN HYDROCHLORIDE

Avelox

BAY 128039

Moxifloxacin Hydrochloride

Has_Free_Acid_Or_Base_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62052

label

Moxifloxacin Hydrochloride

Legacy_Concept_Name

Moxifloxacin

PDQ_Closed_Trial_Search_ID

306456

PDQ_Open_Trial_Search_ID

306456

Preferred_Name

Moxifloxacin Hydrochloride

prefixIRI

ncit:C38696

Semantic_Type

Antibiotic

UMLS_CUI

C0754517

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C795

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http://purl.obolibrary.org/obo/DDO.owl#DDO_0005960 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005960 DMTO LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000306456 PDQ LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/116347002 SNOMEDCT LOOM
http://purl.jp/bio/4/id/200906041229397669 IOBC LOOM
http://purl.bioontology.org/ontology/RXNORM/228750 RXNORM LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0754517 OCHV LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#48589 OCHV LOOM
http://purl.obolibrary.org/obo/CHEBI_7008 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_7008 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_7008 CHEBI LOOM
http://stirdf.jst.go.jp/id/200907086223421999 IOBC LOOM