loading...| Preferred Name |
Carbenicillin |
|
| Synonyms |
CARBENICILLIN Carbenicillin Geopen Pyopen |
|
| Definitions |
A broad-spectrum, semi-synthetic penicillin antibiotic with bactericidal and beta-lactamase resistant activity. Carbenicillin acylates the penicillin-sensitive transpeptidase C-terminal domain by opening the lactam ring. This inactivation prevents the cross-linkage of peptidoglycan strands, thereby inhibiting the third and last stage of bacterial cell wall synthesis. This leads to incomplete bacterial cell wall synthesis and eventually causes cell lysis. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C343 |
|
| CAS_Registry |
4697-36-3 |
|
| CHEBI_ID |
CHEBI:3393 |
|
| Chemical_Formula |
C17H18N2O6S |
|
| code |
C343 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
A broad-spectrum, semi-synthetic penicillin antibiotic with bactericidal and beta-lactamase resistant activity. Carbenicillin acylates the penicillin-sensitive transpeptidase C-terminal domain by opening the lactam ring. This inactivation prevents the cross-linkage of peptidoglycan strands, thereby inhibiting the third and last stage of bacterial cell wall synthesis. This leads to incomplete bacterial cell wall synthesis and eventually causes cell lysis. |
|
| FDA_UNII_Code |
G42ZU72N5G |
|
| FULL_SYN |
CARBENICILLIN Carbenicillin Geopen Pyopen |
|
| Has_Salt_Form | ||
| label |
Carbenicillin |
|
| Legacy Concept Name |
Carbenicillin |
|
| NCI_Drug_Dictionary_ID |
39174 |
|
| PDQ_Closed_Trial_Search_ID |
39174 |
|
| PDQ_Open_Trial_Search_ID |
39174 |
|
| Preferred_Name |
Carbenicillin |
|
| prefixIRI |
Thesaurus:C343 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance Antibiotic |
|
| UMLS_CUI |
C0006976 |
|
| subClassOf |