National Cancer Institute Thesaurus

Last uploaded: October 28, 2019
Preferred Name

Carbenicillin

Synonyms

Geopen

CARBENICILLIN

Carbenicillin

Pyopen

Definitions

A broad-spectrum, semi-synthetic penicillin antibiotic with bactericidal and beta-lactamase resistant activity. Carbenicillin acylates the penicillin-sensitive transpeptidase C-terminal domain by opening the lactam ring. This inactivation prevents the cross-linkage of peptidoglycan strands, thereby inhibiting the third and last stage of bacterial cell wall synthesis. This leads to incomplete bacterial cell wall synthesis and eventually causes cell lysis.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C343

CAS_Registry

4697-36-3

CHEBI_ID

CHEBI:3393

Chemical_Formula

C17H18N2O6S

code

C343

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A broad-spectrum, semi-synthetic penicillin antibiotic with bactericidal and beta-lactamase resistant activity. Carbenicillin acylates the penicillin-sensitive transpeptidase C-terminal domain by opening the lactam ring. This inactivation prevents the cross-linkage of peptidoglycan strands, thereby inhibiting the third and last stage of bacterial cell wall synthesis. This leads to incomplete bacterial cell wall synthesis and eventually causes cell lysis.

FDA_UNII_Code

G42ZU72N5G

FULL_SYN

Geopen

CARBENICILLIN

Carbenicillin

Pyopen

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C65285

label

Carbenicillin

Legacy_Concept_Name

Carbenicillin

NSC_Code

111071

PDQ_Closed_Trial_Search_ID

39174

PDQ_Open_Trial_Search_ID

39174

Preferred_Name

Carbenicillin

prefixIRI

ncit:C343

Semantic_Type

Organic Chemical

Antibiotic

UMLS_CUI

C0006976

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1558

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http://purl.bioontology.org/ontology/NDDF/002700 NDDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.260.825.750.170 RH-MESH LOOM
http://stirdf.jst.go.jp/id/200907028516159482 IOBC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.108.750.750.170 RH-MESH LOOM
http://purl.bioontology.org/ontology/LNC/LP16062-9 LOINC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147746 NDFRT LOOM
http://purl.jp/bio/4/id/200906002830318924 IOBC LOOM
http://purl.bioontology.org/ontology/MESH/D002228 MESH LOOM
http://www.co-ode.org/ontologies/galen#Carbenicillin GALEN LOOM
http://purl.obolibrary.org/obo/DRON_00010407 DRON LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000039174 PDQ LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.075.080.875.099.221.750.750.170 RH-MESH LOOM
http://purl.bioontology.org/ontology/RXNORM/2015 RXNORM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.605.084.737.750.170 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNMI/C-54910 SNMI LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372713001 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/RCD/e42.. RCD LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.065.589.099.750.750.170 RH-MESH LOOM
http://purl.bioontology.org/ontology/VANDF/4019654 VANDF LOOM
http://purl.bioontology.org/ontology/UATC/J01CA03 ATC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU007966 LOINC LOOM
http://purl.obolibrary.org/obo/CHEBI_3393 PHIPO LOOM
http://purl.obolibrary.org/obo/CHEBI_3393 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_3393 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_3393 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_3393 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_3393 GENEPIO LOOM
http://purl.obolibrary.org/obo/CHEBI_3393 NIFSTD LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D002228 RH-MESH LOOM
http://purl.obolibrary.org/obo/ARO_0000043 ARO LOOM