Preferred Name |
Simvastatin |
|
Synonyms |
SIMVASTATIN Simvastatin [1S-[1alpha,3alpha,7beta,8beta(2S*,4S*),8abeta]]-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl 2,2-dimethylbutanoate MK 733 Synvinolin Zocor |
|
Definitions |
A lipid-lowering agent derived synthetically from a fermentation product of the fungus Aspergillus terreus. Hydrolyzed in vivo to an active metabolite, simvastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. (NCI04) |
|
ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29454 |
|
CAS_Registry |
79902-63-9 |
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CHEBI_ID |
CHEBI:9150 |
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Chemical_Formula |
C25H38O5 |
|
code |
C29454 |
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Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
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Contributing_Source |
CTRP FDA |
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DEFINITION |
A lipid-lowering agent derived synthetically from a fermentation product of the fungus Aspergillus terreus. Hydrolyzed in vivo to an active metabolite, simvastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. (NCI04) |
|
Display_Name |
Simvastatin |
|
FDA_UNII_Code |
AGG2FN16EV |
|
FULL_SYN |
SIMVASTATIN Simvastatin [1S-[1alpha,3alpha,7beta,8beta(2S*,4S*),8abeta]]-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl 2,2-dimethylbutanoate MK 733 Synvinolin Zocor |
|
Has_Target | ||
label |
Simvastatin |
|
Legacy Concept Name |
Simvastatin |
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NCI_Drug_Dictionary_ID |
455226 |
|
NSC Number |
633782 |
|
PDQ_Closed_Trial_Search_ID |
455226 |
|
PDQ_Open_Trial_Search_ID |
455226 |
|
Preferred_Name |
Simvastatin |
|
prefixIRI |
Thesaurus:C29454 |
|
Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
UMLS_CUI |
C0074554 |
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subClassOf |