National Cancer Institute Thesaurus

Last uploaded: November 25, 2019
Preferred Name

Simvastatin

Synonyms

MK 733

[1S-[1alpha,3alpha,7beta,8beta(2S*,4S*),8abeta]]-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl 2,2-dimethylbutanoate

Simvastatin

SIMVASTATIN

Zocor

Synvinolin

Definitions

A lipid-lowering agent derived synthetically from a fermentation product of the fungus Aspergillus terreus. Hydrolyzed in vivo to an active metabolite, simvastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. (NCI04)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29454

CAS_Registry

79902-63-9

CHEBI_ID

CHEBI:9150

Chemical_Formula

C25H38O5

code

C29454

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

A lipid-lowering agent derived synthetically from a fermentation product of the fungus Aspergillus terreus. Hydrolyzed in vivo to an active metabolite, simvastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. (NCI04)

Display_Name

Simvastatin

FDA_UNII_Code

AGG2FN16EV

FULL_SYN

MK 733

[1S-[1alpha,3alpha,7beta,8beta(2S*,4S*),8abeta]]-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl 2,2-dimethylbutanoate

Simvastatin

SIMVASTATIN

Zocor

Synvinolin

label

Simvastatin

Legacy_Concept_Name

Simvastatin

NSC_Code

633782

PDQ_Closed_Trial_Search_ID

455226

PDQ_Open_Trial_Search_ID

455226

Preferred_Name

Simvastatin

prefixIRI

ncit:C29454

Semantic_Type

Pharmacologic Substance

Organic Chemical

UMLS_CUI

C0074554

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1655

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http://www.drugbank.ca/drugs/DB00641 FTC LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004003 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004003 DMTO LOOM
http://www.owl-ontologies.com/OntologyXCT.owl#Simvastatin CTX LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.615.638.400.900 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNMI/C-80812 SNMI LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148200 ODAE LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148200 OCVDAE LOOM
http://purl.bioontology.org/ontology/LNC/LP171640-8 LOINC LOOM
http://doe-generated-ontology.com/OntoAD#C0074554 ONTOAD LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#14812 OCHV LOOM
http://www.semanticweb.org/ontologies/STO.owl#b19485ee_419d_4e81_9eac_b7d84ea067ea CVAO LOOM
http://www.semanticweb.org/ontologies/STO.owl#b19485ee_419d_4e81_9eac_b7d84ea067ea STO-DRAFT LOOM
http://purl.bioontology.org/ontology/RXNORM/36567 RXNORM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.455.426.559.847.638.400.900 RH-MESH LOOM
http://www.genomic-cds.org/ont/genomic-cds.owl#Simvastatin GENE-CDS LOOM
http://purl.bioontology.org/ontology/NDDF/003621 NDDF LOOM
http://www.co-ode.org/ontologies/galen#Simvastatin GALEN LOOM
http://scai.fraunhofer.de/AlzheimerOntology#Simvastatin ADO LOOM
http://purl.bioontology.org/ontology/VANDF/4020400 VANDF LOOM
http://purl.bioontology.org/ontology/CSP/5001-0024 CRISP LOOM
https://bioportal.bioontology.org/ontologies/DMTO.owl#DMTO_0001496 DMTO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148200 NDFRT LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005339 DDO LOOM
http://purl.bioontology.org/ontology/RCD/bxd.. RCD LOOM
http://purl.bioontology.org/ontology/MESH/D019821 MESH LOOM
http://stirdf.jst.go.jp/id/200907025396409219 IOBC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0074554 OCHV LOOM
http://purl.obolibrary.org/obo/CHEBI_9150 ODNAE LOOM
http://purl.obolibrary.org/obo/CHEBI_9150 HUPSON LOOM
http://purl.obolibrary.org/obo/CHEBI_9150 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_9150 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_9150 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_9150 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_9150 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_9150 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_9150 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_9150 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_9150 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_9150 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_9150 DIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_9150 NIFSTD LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000455226 PDQ LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387584000 SNOMEDCT LOOM
http://bmi.utah.edu/ontologies/peontology/C0074554 RAO LOOM
http://purl.bioontology.org/ontology/UATC/C10AA01 ATC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D019821 RH-MESH LOOM
http://purl.jp/bio/4/id/200906010113195462 IOBC LOOM