National Cancer Institute Thesaurus

Last uploaded: May 28, 2019
Preferred Name

Risperidone

Synonyms

Risperidone

RISPERIDONE

Definitions

A benzisoxazole derivative with antipsychotic property. Risperidone selectively antagonizes serotonin (5-HT) effects via cortical 5-HT2 receptor, and, to a lesser extent, competes with dopamine at the limbic dopamine D2 receptor. The antagonism leads to decreased psychotic effects, such as hallucinations and delusions. In addition, risperidone has low to moderate affinity for histamine H1, 5-HT1A, 5-HT1C, and 5-HT1D receptors, while it has weak affinity for dopamine D1 and haloperidol-sensitive sigma site receptors.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29416

CAS_Registry

106266-06-2

CHEBI_ID

CHEBI:8871

Chemical_Formula

C23H27FN4O2

code

C29416

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A benzisoxazole derivative with antipsychotic property. Risperidone selectively antagonizes serotonin (5-HT) effects via cortical 5-HT2 receptor, and, to a lesser extent, competes with dopamine at the limbic dopamine D2 receptor. The antagonism leads to decreased psychotic effects, such as hallucinations and delusions. In addition, risperidone has low to moderate affinity for histamine H1, 5-HT1A, 5-HT1C, and 5-HT1D receptors, while it has weak affinity for dopamine D1 and haloperidol-sensitive sigma site receptors.

FDA_UNII_Code

L6UH7ZF8HC

FULL_SYN

Risperidone

RISPERIDONE

label

Risperidone

Legacy_Concept_Name

Risperidone

Preferred_Name

Risperidone

prefixIRI

ncit:C29416

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0073393

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29710

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http://purl.bioontology.org/ontology/VANDF/4020840 VANDF LOOM
http://stirdf.jst.go.jp/id/200907081517625922 IOBC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU014878 LOINC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.742.698.685 RH-MESH LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005427 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005427 DMTO LOOM
http://www.case.edu/EpSO.owl#Risperidone EPSO LOOM
http://purl.bioontology.org/ontology/CSP/4007-0111 CRISP LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D018967 RH-MESH LOOM
http://purl.obolibrary.org/obo/CHEBI_8871 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_8871 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_8871 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_8871 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_8871 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_8871 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_8871 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_8871 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_8871 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_8871 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_8871 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_8871 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_8871 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_8871 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_8871 NIFSTD LOOM
http://www.co-ode.org/ontologies/galen#Risperidone GALEN LOOM
http://purl.bioontology.org/ontology/MESH/D018967 MESH LOOM
http://scai.fraunhofer.de/AlzheimerOntology#risperidone ADO LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/386840002 SNOMEDCT LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004347 FASTO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004347 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004347 DMTO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148350 NDFRT LOOM
http://purl.bioontology.org/ontology/LNC/LP17872-0 LOINC LOOM
http://purl.bioontology.org/ontology/UATC/N05AX08 ATC LOOM
http://purl.bioontology.org/ontology/RXNORM/35636 RXNORM LOOM
http://purl.bioontology.org/ontology/RCD/d4p.. RCD LOOM
http://www.drugbank.ca/drugs/DB00734 FTC LOOM
http://purl.bioontology.org/ontology/NDDF/004392 NDDF LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Risperidone APAONTO LOOM
http://purl.jp/bio/4/id/200906002745668037 IOBC LOOM