National Cancer Institute Thesaurus

Last uploaded: March 25, 2019
Preferred Name

Glycerin

Synonyms

Glycerin

GLYCERIN

Glycerol

1,2,3-Propanetriol

Definitions

A trihydroxyalcohol with localized osmotic diuretic and laxative effects. Glycerin elevates the blood plasma osmolality thereby extracting water from tissues into interstitial fluid and plasma. This agent also prevents water reabsorption in the proximal tubule in the kidney leading to an increase in water and sodium excretion and a reduction in blood volume. Administered rectally, glycerin exerts a hyperosmotic laxative effect by attracting water into the rectum, thereby relieving constipation. In addition, glycerin is used as a solvent, humectant and vehicle in various pharmaceutical preparations.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29077

CAS_Registry

56-81-5

CHEBI_ID

CHEBI:17754

Chemical_Formula

C3H8O3

code

C29077

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799

Contributing_Source

CTRP

FDA

DEFINITION

A trihydroxyalcohol with localized osmotic diuretic and laxative effects. Glycerin elevates the blood plasma osmolality thereby extracting water from tissues into interstitial fluid and plasma. This agent also prevents water reabsorption in the proximal tubule in the kidney leading to an increase in water and sodium excretion and a reduction in blood volume. Administered rectally, glycerin exerts a hyperosmotic laxative effect by attracting water into the rectum, thereby relieving constipation. In addition, glycerin is used as a solvent, humectant and vehicle in various pharmaceutical preparations.

Display_Name

Glycerin

FDA_UNII_Code

PDC6A3C0OX

FULL_SYN

Glycerin

GLYCERIN

Glycerol

1,2,3-Propanetriol

label

Glycerin

Legacy_Concept_Name

Glycerin

NSC_Code

9230

Preferred_Name

Glycerin

prefixIRI

ncit:C29077

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0017861

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29697

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http://d-nb.info/gnd/4157721-8 FAST-TOPICAL LOOM
http://purl.bioontology.org/ontology/NDDF/002469 NDDF LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000145799 NDFRT LOOM
http://purl.bioontology.org/ontology/VANDF/4017411 VANDF LOOM
http://neuromorpho.org/ontologies/objectivetypeH.owl#NMOOt_487 NMOBR LOOM
http://purl.obolibrary.org/obo/CHEBI_17754 DRON LOOM
http://purl.bioontology.org/ontology/NDDF/002240 NDDF LOOM
http://purl.bioontology.org/ontology/NDDF/001176 NDDF LOOM
http://neuromorpho.org/ontologies/1/objectivetypeH.owl#NMOOt_487 NMOBR LOOM
http://purl.bioontology.org/ontology/RXNORM/4910 RXNORM LOOM
http://id.loc.gov/authorities/subjects/sh85055393 FAST-TOPICAL LOOM
http://purl.bioontology.org/ontology/NDDF/001893 NDDF LOOM
http://purl.bioontology.org/ontology/SNMI/C-96060 SNMI LOOM