National Cancer Institute Thesaurus

Last uploaded: August 27, 2019
Preferred Name

Cyclobenzaprine

Synonyms

Cyclobenzaprine

CYCLOBENZAPRINE

Amrix

Definitions

A centrally acting skeletal muscle relaxant with antidepressant activity. The exact mechanism of action of cyclobenzaprine has not been fully determined, but this drug seems to primarily act at the brain stem to reduce tonic somatic motor activity, influencing both gamma and alpha motor neurons leading to a reduction in muscle spasms.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28947

Accepted_Therapeutic_Use_For

Muscle Spasm

CAS_Registry

303-53-7

CHEBI_ID

CHEBI:3996

Chemical_Formula

C20H21N

code

C28947

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A centrally acting skeletal muscle relaxant with antidepressant activity. The exact mechanism of action of cyclobenzaprine has not been fully determined, but this drug seems to primarily act at the brain stem to reduce tonic somatic motor activity, influencing both gamma and alpha motor neurons leading to a reduction in muscle spasms.

FDA_UNII_Code

69O5WQQ5TI

FULL_SYN

Cyclobenzaprine

CYCLOBENZAPRINE

Amrix

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47465

label

Cyclobenzaprine

Legacy_Concept_Name

Cyclobenzaprine

Preferred_Name

Cyclobenzaprine

prefixIRI

ncit:C28947

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0056732

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29696

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http://purl.bioontology.org/ontology/SNOMEDCT/373779004 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/LNC/LP17189-9 LOINC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU004256 LOINC LOOM
http://purl.obolibrary.org/obo/CHEBI_3996 ODNAE LOOM
http://purl.obolibrary.org/obo/CHEBI_3996 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_3996 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_3996 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_3996 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_3996 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_3996 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_3996 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_3996 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_3996 CHEBI LOOM
http://purl.bioontology.org/ontology/MESH/C004704 MESH LOOM
http://purl.bioontology.org/ontology/VANDF/4019699 VANDF LOOM
http://purl.bioontology.org/ontology/UATC/M03BX08 ATC LOOM
http://www.drugbank.ca/drugs/DB00924 FTC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C004704 RH-MESH LOOM
http://purl.bioontology.org/ontology/RXNORM/21949 RXNORM LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147791 NDFRT LOOM
http://purl.bioontology.org/ontology/SNMI/C-687C0 SNMI LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000147791 ODAE LOOM