Preferred Name |
Chloral Hydrate |
|
Synonyms |
CHLORAL HYDRATE Chloral Hydrate |
|
Definitions |
A synthetic monohydrate of chloral with sedative, hypnotic, and anticonvulsive properties. Chloral hydrate is converted to the active compound trichloroethanol by hepatic alcohol dehydrogenase. The agent interacts with various neurotransmitter-operated ion channels, thereby enhancing gamma-aminobutyric acid (GABA)-A receptor mediated chloride currents and inhibiting amino acid receptor-activated ion currents. In addition, chloral hydrate enhances the agonistic effects of glycine receptors, inhibits AMPA-induced calcium influx in cortical neurons, and facilitates 5-HT 3 receptor-mediated currents in ganglionic neurons. Overall, this results in a depressive effect on the central nervous system. |
|
ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28922 |
|
CAS_Registry |
302-17-0 |
|
CHEBI_ID |
CHEBI:28142 |
|
Chemical_Formula |
C2H3Cl3O2 |
|
code |
C28922 |
|
Concept_In_Subset | ||
Contributing_Source |
FDA |
|
DEFINITION |
A synthetic monohydrate of chloral with sedative, hypnotic, and anticonvulsive properties. Chloral hydrate is converted to the active compound trichloroethanol by hepatic alcohol dehydrogenase. The agent interacts with various neurotransmitter-operated ion channels, thereby enhancing gamma-aminobutyric acid (GABA)-A receptor mediated chloride currents and inhibiting amino acid receptor-activated ion currents. In addition, chloral hydrate enhances the agonistic effects of glycine receptors, inhibits AMPA-induced calcium influx in cortical neurons, and facilitates 5-HT 3 receptor-mediated currents in ganglionic neurons. Overall, this results in a depressive effect on the central nervous system. |
|
FDA_UNII_Code |
418M5916WG |
|
FULL_SYN |
CHLORAL HYDRATE Chloral Hydrate |
|
label |
Chloral Hydrate |
|
Legacy Concept Name |
Chloral_Hydrate |
|
Preferred_Name |
Chloral Hydrate |
|
prefixIRI |
Thesaurus:C28922 |
|
Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
UMLS_CUI |
C0008161 |
|
subClassOf |