loading...| Preferred Name |
Cefpodoxime Proxetil |
|
| Synonyms |
CEFPODOXIME PROXETIL Cefpodoxime Proxetil Vantin |
|
| Definitions |
A third generation semi-synthetic cephalosporin and a beta-lactam antibiotic with bactericidal activity. Cefpodoxime's effect is dependent on its binding to penicillin-binding proteins (PBPs) located in the bacterial cytoplasmic membrane. Binding results in the inhibition of the transpeptidase enzymes, thereby preventing cross-linking of the pentaglycine bridge with the fourth residue of the pentapeptide and interrupting consequent synthesis of peptidoglycan chains. As a result, cefpodoxime inhibits bacterial septum and cell wall synthesis formation. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28916 |
|
| CAS_Registry |
87239-81-4 |
|
| CHEBI_ID |
CHEBI:3505 |
|
| code |
C28916 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
| Contributing_Source |
CTRP FDA |
|
| DEFINITION |
A third generation semi-synthetic cephalosporin and a beta-lactam antibiotic with bactericidal activity. Cefpodoxime's effect is dependent on its binding to penicillin-binding proteins (PBPs) located in the bacterial cytoplasmic membrane. Binding results in the inhibition of the transpeptidase enzymes, thereby preventing cross-linking of the pentaglycine bridge with the fourth residue of the pentapeptide and interrupting consequent synthesis of peptidoglycan chains. As a result, cefpodoxime inhibits bacterial septum and cell wall synthesis formation. |
|
| Display_Name |
Cefpodoxime Proxetil |
|
| FDA_UNII_Code |
2TB00A1Z7N |
|
| FULL_SYN |
CEFPODOXIME PROXETIL Cefpodoxime Proxetil Vantin |
|
| label |
Cefpodoxime Proxetil |
|
| Legacy Concept Name |
Cefpodoxime |
|
| NCI_Drug_Dictionary_ID |
455227 |
|
| PDQ_Closed_Trial_Search_ID |
455227 |
|
| PDQ_Open_Trial_Search_ID |
455227 |
|
| Preferred_Name |
Cefpodoxime Proxetil |
|
| prefixIRI |
Thesaurus:C28916 |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance Antibiotic |
|
| UMLS_CUI |
C0108938 |
|
| subClassOf |