National Cancer Institute Thesaurus

Last uploaded: August 27, 2019
Preferred Name

Cefazolin

Synonyms

CEFAZOLIN

Cefazolin

(6R,7R)-3-(((5-Methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-7-(2-(1H-tetrazol-1-yl)acetamido)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid

Definitions

A beta-lactam antibiotic and first-generation cephalosporin with bactericidal activity. Cefazolin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28913

CAS_Registry

25953-19-9

CHEBI_ID

CHEBI:474053

Chemical_Formula

C14H14N8O4S3

code

C28913

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

A beta-lactam antibiotic and first-generation cephalosporin with bactericidal activity. Cefazolin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.

Display_Name

Cefazolin

FDA_UNII_Code

IHS69L0Y4T

FULL_SYN

CEFAZOLIN

Cefazolin

(6R,7R)-3-(((5-Methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-7-(2-(1H-tetrazol-1-yl)acetamido)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47968

label

Cefazolin

Legacy_Concept_Name

Cefazolin

Preferred_Name

Cefazolin

prefixIRI

ncit:C28913

Semantic_Type

Organic Chemical

Antibiotic

UMLS_CUI

C0007546

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C357

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http://purl.jp/bio/4/id/200906094247549391 IOBC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.075.080.875.099.221.249.160 RH-MESH LOOM
http://purl.bioontology.org/ontology/RXNORM/2180 RXNORM LOOM
http://purl.bioontology.org/ontology/MESH/D002437 MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.665.074.160 RH-MESH LOOM
http://purl.bioontology.org/ontology/LNC/MTHU005579 LOINC LOOM
http://purl.obolibrary.org/obo/CHEBI_474053 PHIPO LOOM
http://purl.obolibrary.org/obo/CHEBI_474053 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_474053 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_474053 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_474053 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_474053 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_474053 GENEPIO LOOM
http://purl.obolibrary.org/obo/CHEBI_474053 DRON LOOM
http://purl.bioontology.org/ontology/NDDF/004841 NDDF LOOM
http://purl.bioontology.org/ontology/UATC/J01DB04 ATC LOOM
http://purl.obolibrary.org/obo/ARO_0000058 ARO LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387470007 SNOMEDCT LOOM
http://www.co-ode.org/ontologies/galen#Cefazolin GALEN LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D002437 RH-MESH LOOM
http://stirdf.jst.go.jp/id/200907057147714728 IOBC LOOM
http://purl.bioontology.org/ontology/LNC/LP16066-0 LOINC LOOM
http://www.drugbank.ca/drugs/DB01327 FTC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.065.589.099.249.160 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147751 NDFRT LOOM
http://purl.bioontology.org/ontology/VANDF/4019659 VANDF LOOM