National Cancer Institute Thesaurus

Last uploaded: June 25, 2019
Preferred Name

Vascular Endothelial Growth Factor Receptor 3

Synonyms

FMS-Like Tyrosine Kinase 4

Vascular Endothelial Growth Factor Receptor 3

VEGFR-3

Tyrosine-Protein Kinase Receptor FLT4

AV3

EC 2.7.10.1

FLT4

VEGFR3

FMS-Related Tyrosine Kinase 4

Definitions

Vascular endothelial growth factor receptor 3 (1363 aa, ~153 kDa) is encoded by the human FLT4 gene. This protein is involved in tyrosine phosphorylation, lymph vessel formation and ligand-dependent signaling.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26203

code

C26203

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142800

Contributing_Source

CTRP

DEFINITION

Vascular endothelial growth factor receptor 3 (1363 aa, ~153 kDa) is encoded by the human FLT4 gene. This protein is involved in tyrosine phosphorylation, lymph vessel formation and ligand-dependent signaling.

DesignNote

A type I membrane protein tyrosine kinase receptor for VEGF-C, vascular endothelial growth factor receptor 3, contains seven immunoglobulin-like C2-type domains. Vascular endothelial growth factors, working through VEGF receptor-3, promote angiogenesis and metastatic spread of cancer cells. (from Nat Med 2001. 7:151 & 186)

Display_Name

Vascular Endothelial Growth Factor Receptor 3

FULL_SYN

FMS-Like Tyrosine Kinase 4

Vascular Endothelial Growth Factor Receptor 3

VEGFR-3

Tyrosine-Protein Kinase Receptor FLT4

AV3

EC 2.7.10.1

FLT4

VEGFR3

FMS-Related Tyrosine Kinase 4

label

Vascular Endothelial Growth Factor Receptor 3

Legacy_Concept_Name

FMS-Related_Tyrosine_Kinase-4

OMIM_Number

136352

Preferred_Name

Vascular Endothelial Growth Factor Receptor 3

prefixIRI

ncit:C26203

Semantic_Type

Receptor

Amino Acid, Peptide, or Protein

Swiss_Prot

P35916

UMLS_CUI

C3657407

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17660

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