loading...| Preferred Name |
Psoralen |
| Synonyms |
6-hydroxy-5-benzofuranacrylic Acid deta-lacton psoralen Psoralen PSORALEN Ficusin |
| Definitions |
A furocoumarin that intercalates with DNA, inhibiting DNA synthesis and cell division. Psoralen is used in Photochemotherapy with high-intensity long-wavelength UVA irradiation. Psoralens are tricyclic furocumarins and have a strong tendency to intercalate with DNA base pairs. Irradiation of nucleic acids in the presence of psoralen with long wave UV (~360 nm) results in the 2+2 cyclo- addition of either of its two photoreactive sites with 5,6-carbon bonds of pyrimidines resulting in crosslinking double-stranded nucleic acids. |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2586 |
| Accepted_Therapeutic_Use_For |
Psoriasis; T-cell Lymphoma-Cutaneous; Vitiligo |
| ALT_DEFINITION |
A substance from plants that is sensitive to light (or can be activated by light). Psoralens are used together with UV light to treat psoriasis, vitiligo, and skin nodules of cutaneous T-cell lymphoma. They are also being studied in the treatment of graft-versus-host disease. Psoralen is a type of furocoumarin. An example of a psoralen is methoxsalen. |
| CAS_Registry |
66-97-7 |
| CHEBI_ID |
CHEBI:27616 |
| Chemical_Formula |
C11H6O3 |
| code |
C2586 |
| Concept_In_Subset | |
| Contributing_Source |
FDA |
| DEFINITION |
A furocoumarin that intercalates with DNA, inhibiting DNA synthesis and cell division. Psoralen is used in Photochemotherapy with high-intensity long-wavelength UVA irradiation. Psoralens are tricyclic furocumarins and have a strong tendency to intercalate with DNA base pairs. Irradiation of nucleic acids in the presence of psoralen with long wave UV (~360 nm) results in the 2+2 cyclo- addition of either of its two photoreactive sites with 5,6-carbon bonds of pyrimidines resulting in crosslinking double-stranded nucleic acids. |
| FDA_UNII_Code |
KTZ7ZCN2EX |
| FULL_SYN |
6-hydroxy-5-benzofuranacrylic Acid deta-lacton psoralen Psoralen PSORALEN Ficusin |
| label |
Psoralen |
| Legacy_Concept_Name |
Psoralen |
| NSC_Code |
217989 |
| PDQ_Closed_Trial_Search_ID |
37899 |
| PDQ_Open_Trial_Search_ID |
37899 |
| Preferred_Name |
Psoralen |
| prefixIRI |
ncit:C2586 |
| Semantic_Type |
Pharmacologic Substance Organic Chemical |
| UMLS_CUI |
C0016072 |
| subClassOf |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C582 |