National Cancer Institute Thesaurus

Last uploaded: September 30, 2019
Preferred Name

Psoralen

Synonyms

6-hydroxy-5-benzofuranacrylic Acid deta-lacton

psoralen

Psoralen

PSORALEN

Ficusin

Definitions

A furocoumarin that intercalates with DNA, inhibiting DNA synthesis and cell division. Psoralen is used in Photochemotherapy with high-intensity long-wavelength UVA irradiation. Psoralens are tricyclic furocumarins and have a strong tendency to intercalate with DNA base pairs. Irradiation of nucleic acids in the presence of psoralen with long wave UV (~360 nm) results in the 2+2 cyclo- addition of either of its two photoreactive sites with 5,6-carbon bonds of pyrimidines resulting in crosslinking double-stranded nucleic acids.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2586

Accepted_Therapeutic_Use_For

Psoriasis; T-cell Lymphoma-Cutaneous; Vitiligo

ALT_DEFINITION

A substance from plants that is sensitive to light (or can be activated by light). Psoralens are used together with UV light to treat psoriasis, vitiligo, and skin nodules of cutaneous T-cell lymphoma. They are also being studied in the treatment of graft-versus-host disease. Psoralen is a type of furocoumarin. An example of a psoralen is methoxsalen.

CAS_Registry

66-97-7

CHEBI_ID

CHEBI:27616

Chemical_Formula

C11H6O3

code

C2586

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A furocoumarin that intercalates with DNA, inhibiting DNA synthesis and cell division. Psoralen is used in Photochemotherapy with high-intensity long-wavelength UVA irradiation. Psoralens are tricyclic furocumarins and have a strong tendency to intercalate with DNA base pairs. Irradiation of nucleic acids in the presence of psoralen with long wave UV (~360 nm) results in the 2+2 cyclo- addition of either of its two photoreactive sites with 5,6-carbon bonds of pyrimidines resulting in crosslinking double-stranded nucleic acids.

FDA_UNII_Code

KTZ7ZCN2EX

FULL_SYN

6-hydroxy-5-benzofuranacrylic Acid deta-lacton

psoralen

Psoralen

PSORALEN

Ficusin

label

Psoralen

Legacy_Concept_Name

Psoralen

NSC_Code

217989

PDQ_Closed_Trial_Search_ID

37899

PDQ_Open_Trial_Search_ID

37899

Preferred_Name

Psoralen

prefixIRI

ncit:C2586

Semantic_Type

Pharmacologic Substance

Organic Chemical

UMLS_CUI

C0016072

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C582

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2163

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25760

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Delete Mapping To Ontology Source
http://sbmi.uth.tmc.edu/ontology/ochv#C0016072 OCHV LOOM
http://purl.obolibrary.org/obo/XLMOD_00134 XLMOD LOOM
http://purl.bioontology.org/ontology/RCD/X7980 RCD LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/419047007 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/CSP/0397-0344 CRISP LOOM
http://purl.bioontology.org/ontology/RXNORM/2103294 RXNORM LOOM
http://purl.obolibrary.org/obo/CHEBI_27616 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_27616 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_27616 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_27616 OCMR LOOM
http://purl.obolibrary.org/obo/CHEBI_27616 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_27616 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_27616 NIFSTD LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000037899 PDQ LOOM