loading...| Preferred Name |
Mercaptopurine |
|
| Synonyms |
Purine, 6-mercapto- Puri-Nethol MERCAPTOPURINE Purine-6-thiol (8CI) Mercaptopurine 6-Mercaptopurine 6 Thiohypoxanthine Purine-6-thiol, Monohydrate 6H-Purine-6-thione, 1,7-dihydro- (9CI) Mercaptopurinum Purine-6-thiol Monohydrate 6-Purinethiol Alti-Mercaptopurine 1,7-Dihydro-6H-purine-6-thione Mercapto-6-purine 6-Thiopurine 1,7-Dihydro-6H-purine-6-thione Monohydrate 6 Thiopurine Purine-6-thiol, monohydrate mercaptopurine Purinethiol 7-Mercapto-1,3,4,6-tetrazaindene 6-Thioxopurine 3H-Purine-6-thiol 6-Mercaptopurine Monohydrate Mercaleukin Mercaleukim Azathiopurine 6 MP 6-MP BW 57-323H Bw 57-323H Flocofil Ismipur Leukerin Leupurin Mercaptina Mercapurin Mern NCI-C04886 Purimethol Purinethol U-4748 WR-2785 |
|
| Definitions |
A thiopurine-derivative antimetabolite with antineoplastic and immunosuppressive activities. Produced through the metabolism of mercaptopurine by hypoxanthine-guanine phosphoribosyltransferase (HGPRT), mercaptopurine metabolites 6-thioguanosine-5'-phosphate (6-thioGMP) and 6-thioinosine monophosphate (T-IMP) inhibit nucleotide interconversions and de novo purine synthesis, thereby blocking the formation of purine nucleotides and inhibiting DNA synthesis. This agent is also incorporated into DNA in the form of deoxythioguanosine, which results in the disruption of DNA replication. In addition, mercaptopurine is converted to 6-methylmercaptopurine ribonucleoside (MMPR) by 6-thiopurine methyltransferase; MMPRs are also potent inhibitors of de novo purine synthesis. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C195 |
|
| Accepted_Therapeutic_Use_For |
Acute lymphocytic leukemia; Acute myelogenous leukemia; Crohns disease; Hodgkins lymphoma in children; Lymphoblastic lymphoma; Ulcerative colitis |
|
| ALT_DEFINITION |
A drug used to treat acute lymphatic leukemia. It belongs to the family of drugs called antimetabolites. |
|
| CAS_Registry |
6112-76-1 |
|
| CHEBI_ID |
CHEBI:31822 |
|
| Chemical_Formula |
C5H4N4S.H2O |
|
| code |
C195 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
CTRP FDA GDC HemOnc |
|
| DEFINITION |
A thiopurine-derivative antimetabolite with antineoplastic and immunosuppressive activities. Produced through the metabolism of mercaptopurine by hypoxanthine-guanine phosphoribosyltransferase (HGPRT), mercaptopurine metabolites 6-thioguanosine-5'-phosphate (6-thioGMP) and 6-thioinosine monophosphate (T-IMP) inhibit nucleotide interconversions and de novo purine synthesis, thereby blocking the formation of purine nucleotides and inhibiting DNA synthesis. This agent is also incorporated into DNA in the form of deoxythioguanosine, which results in the disruption of DNA replication. In addition, mercaptopurine is converted to 6-methylmercaptopurine ribonucleoside (MMPR) by 6-thiopurine methyltransferase; MMPRs are also potent inhibitors of de novo purine synthesis. (NCI04) |
|
| Display_Name |
Mercaptopurine |
|
| FDA_UNII_Code |
E7WED276I5 |
|
| FULL_SYN |
Purine, 6-mercapto- Puri-Nethol MERCAPTOPURINE Purine-6-thiol (8CI) Mercaptopurine 6-Mercaptopurine 6 Thiohypoxanthine Purine-6-thiol, Monohydrate 6H-Purine-6-thione, 1,7-dihydro- (9CI) Mercaptopurinum Purine-6-thiol Monohydrate 6-Purinethiol Alti-Mercaptopurine 1,7-Dihydro-6H-purine-6-thione Mercapto-6-purine 6-Thiopurine 1,7-Dihydro-6H-purine-6-thione Monohydrate 6 Thiopurine Purine-6-thiol, monohydrate mercaptopurine Purinethiol 7-Mercapto-1,3,4,6-tetrazaindene 6-Thioxopurine 3H-Purine-6-thiol 6-Mercaptopurine Monohydrate Mercaleukin Mercaleukim Azathiopurine 6 MP 6-MP BW 57-323H Bw 57-323H Flocofil Ismipur Leukerin Leupurin Mercaptina Mercapurin Mern NCI-C04886 Purimethol Purinethol U-4748 WR-2785 |
|
| Is_Value_For_GDC_Property | ||
| label |
Mercaptopurine |
|
| Legacy Concept Name |
Mercaptopurine |
|
| Maps_To |
Mercaptopurine |
|
| NCI_Drug_Dictionary_ID |
43436 |
|
| NSC Number |
755 |
|
| PDQ_Closed_Trial_Search_ID |
43436 |
|
| PDQ_Open_Trial_Search_ID |
43436 |
|
| Preferred_Name |
Mercaptopurine |
|
| prefixIRI |
Thesaurus:C195 |
|
| Semantic_Type |
Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide |
|
| UMLS_CUI |
C0000618 |
|
| subClassOf |