National Cancer Institute Thesaurus

Last uploaded: September 30, 2019
Preferred Name

Capecitabine

Synonyms

5'-Deoxy-5-fluoro-N-[(pentyloxy)carbonyl]-cytidine

Xeloda

capecitabine

Ro 09-1978/000

Capecitabine

CAPECITABINE

Definitions

A fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is selectively activated by tumor cells to its cytotoxic moiety, 5-fluorouracil (5-FU); subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells. FdUMP inhibits DNA synthesis and cell division by reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate for incorporation into the RNA strand. (NCI04)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1794

Accepted_Therapeutic_Use_For

Breast cancer; Colorectal cancer, Stage III colon cancer

ALT_DEFINITION

A drug used to treat stage III colon cancer in patients who had surgery to remove the cancer. It is also used to treat metastatic breast cancer that has not improved after treatment with certain other anticancer drugs. Xeloda is being studied in the treatment of other types of cancer. It is taken up by cancer cells and breaks down into 5-fluorouracil, a substance that kills tumor cells. Xeloda is a type of antimetabolite.

CAS_Registry

154361-50-9

CHEBI_ID

CHEBI:31348

Chemical_Formula

C15H22FN3O6

code

C1794

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

A fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is selectively activated by tumor cells to its cytotoxic moiety, 5-fluorouracil (5-FU); subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells. FdUMP inhibits DNA synthesis and cell division by reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate for incorporation into the RNA strand. (NCI04)

Display_Name

Capecitabine

FDA_UNII_Code

6804DJ8Z9U

FULL_SYN

5'-Deoxy-5-fluoro-N-[(pentyloxy)carbonyl]-cytidine

Xeloda

capecitabine

Ro 09-1978/000

Capecitabine

CAPECITABINE

label

Capecitabine

Legacy_Concept_Name

Capecitabine

NSC_Code

712807

PDQ_Closed_Trial_Search_ID

42852

PDQ_Open_Trial_Search_ID

42852

Preferred_Name

Capecitabine

prefixIRI

ncit:C1794

Semantic_Type

Pharmacologic Substance

Nucleic Acid, Nucleoside, or Nucleotide

UMLS_CUI

C0671970

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1557

Delete Subject Author Type Created
No notes to display
Create New Mapping

Delete Mapping To Ontology Source
http://sbmi.uth.tmc.edu/ontology/ochv#C0671970 OCHV LOOM
http://purl.bioontology.org/ontology/MESH/D000069287 MESH LOOM
http://scai.fraunhofer.de/HuPSON#SCAIVPH_00001231 HUPSON LOOM
http://purl.bioontology.org/ontology/UATC/L01BC06 ATC LOOM
http://purl.bioontology.org/ontology/RXNORM/194000 RXNORM LOOM
http://purl.bioontology.org/ontology/RXNORM/194000 NLMVS LOOM
http://stirdf.jst.go.jp/id/200907014108577410 IOBC LOOM
http://purl.jp/bio/4/id/200906036949004326 IOBC LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148555 ODAE LOOM
http://purl.obolibrary.org/obo/DRON_00010402 ODNAE LOOM
http://purl.obolibrary.org/obo/DRON_00010402 DRON LOOM
http://purl.obolibrary.org/obo/DRON_00010402 DRON LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148555 NDFRT LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/386906001 SNOMEDCT LOOM
http://www.drugbank.ca/drugs/DB01101 FTC LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1794 ROO LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1794 ROO SAME_URI
http://sbmi.uth.tmc.edu/ontology/ochv#42556 OCHV LOOM
http://www.co-ode.org/ontologies/galen#Capecitabine GALEN LOOM
http://purl.bioontology.org/ontology/VANDF/4021099 VANDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C110904 RH-MESH LOOM
http://purl.obolibrary.org/obo/CHEBI_31348 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_31348 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_31348 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_31348 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_31348 NIFSTD LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000042852 PDQ LOOM