loading...| Preferred Name |
Omapatrilat |
|
| Synonyms |
OMAPATRILAT Omapatrilat (4S,7S,10aS)-Octahydro-4-((S)-Alpha-Mercaptohydrocinnamamido)-5-Oxo-7H-Pyrido(2,1-B)(1,3)Thiazepine-7-Carboxylic Acid BMS-186716-01 Omapatrilate BMS-186716 Vanlev |
|
| Definitions |
A vasopeptidase inhibitor with antihypertensive activity. Omapatrilat exerts its effect by inhibiting angiotensin converting enzyme (ACE) and neutral endopeptidase (NEP). ACE inhibition results in inhibition of the renin-angiotensin-aldosterone system thereby leading to the reduction of vasoconstriction. Inhibition of NEP leads to the inhibition of hydrolyzation of a number of endogenous vasoactive peptides, such as bradykinin and substance P and as NEP is the principal enzyme degrading natriuretic peptides, NEP inhibition also results in an increase in natriuretic peptidase circulation. Ultimately both effects result in blood vessel relaxation. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1782 |
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| CAS_Registry |
167305-00-2 |
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| Chemical_Formula |
C19H24N2O4S2 |
|
| code |
C1782 |
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| Concept_In_Subset | ||
| Contributing_Source |
FDA |
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| DEFINITION |
A vasopeptidase inhibitor with antihypertensive activity. Omapatrilat exerts its effect by inhibiting angiotensin converting enzyme (ACE) and neutral endopeptidase (NEP). ACE inhibition results in inhibition of the renin-angiotensin-aldosterone system thereby leading to the reduction of vasoconstriction. Inhibition of NEP leads to the inhibition of hydrolyzation of a number of endogenous vasoactive peptides, such as bradykinin and substance P and as NEP is the principal enzyme degrading natriuretic peptides, NEP inhibition also results in an increase in natriuretic peptidase circulation. Ultimately both effects result in blood vessel relaxation. |
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| FDA_UNII_Code |
36NLI90E7T |
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| FULL_SYN |
OMAPATRILAT Omapatrilat (4S,7S,10aS)-Octahydro-4-((S)-Alpha-Mercaptohydrocinnamamido)-5-Oxo-7H-Pyrido(2,1-B)(1,3)Thiazepine-7-Carboxylic Acid BMS-186716-01 Omapatrilate BMS-186716 Vanlev |
|
| label |
Omapatrilat |
|
| Legacy Concept Name |
Omapatrilat |
|
| Preferred_Name |
Omapatrilat |
|
| prefixIRI |
Thesaurus:C1782 |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0663645 |
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| subClassOf |