loading...| Preferred Name |
Mepolizumab |
|
| Synonyms |
Mepolizumab MEPOLIZUMAB Bosatria Nucala SB 240563 SB-240563 SB240563 |
|
| Definitions |
A humanized immunoglobulin G1 (IgG1) monoclonal antibody directed against interleukin-5 (IL-5) with anti-asthmatic and potential immunosuppressive activity. Upon subcutaneous administration, mepolizumab selectively binds to IL-5, preventing it from associating with interleukin-5 receptor subunit alpha (IL5RA) on the surface of eosinophils and their progenitors. IL-5 plays a role in the regulation of eosinophil development from hematopoietic progenitors as well as eosinophil maturation, differentiation, mobilization, activation, and survival. IL-5 also play a role in the pathogenesis of some phenotypes of hypereosinophilic syndrome (HES). |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157376 |
|
| CAS_Registry |
196078-29-2 |
|
| code |
C157376 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 |
|
| Contributing_Source |
CTRP FDA HemOnc |
|
| DEFINITION |
A humanized immunoglobulin G1 (IgG1) monoclonal antibody directed against interleukin-5 (IL-5) with anti-asthmatic and potential immunosuppressive activity. Upon subcutaneous administration, mepolizumab selectively binds to IL-5, preventing it from associating with interleukin-5 receptor subunit alpha (IL5RA) on the surface of eosinophils and their progenitors. IL-5 plays a role in the regulation of eosinophil development from hematopoietic progenitors as well as eosinophil maturation, differentiation, mobilization, activation, and survival. IL-5 also play a role in the pathogenesis of some phenotypes of hypereosinophilic syndrome (HES). |
|
| Display_Name |
Mepolizumab |
|
| FDA_UNII_Code |
90Z2UF0E52 |
|
| FULL_SYN |
Mepolizumab MEPOLIZUMAB Bosatria Nucala SB 240563 SB-240563 SB240563 |
|
| Has_Target | ||
| label |
Mepolizumab |
|
| NCI_Drug_Dictionary_ID |
796922 |
|
| NCI_META_CUI |
CL936998 |
|
| PDQ_Closed_Trial_Search_ID |
796922 |
|
| PDQ_Open_Trial_Search_ID |
796922 |
|
| Preferred_Name |
Mepolizumab |
|
| prefixIRI |
Thesaurus:C157376 |
|
| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance |
|
| subClassOf |