Preferred Name |
Daclizumab |
|
Synonyms |
Anti-Tac Monoclonal Antibody Monoclonal Antibody Anti-Tac Anti-Tac Humanized Monoclonal Antibody Humanized Anti-Tac Monoclonal Antibody Anti-Tac DACLIZUMAB Dacliximab Daclizumab Zenapax daclizumab |
|
Definitions |
A recombinant monoclonal antibody interleukin-2 receptor antagonist. Daclizumab binds specifically to the alpha subunit of the human interleukin-2 (IL-2) receptor expressed on the surface of activated lymphocytes in vivo, thereby inhibiting IL-2 binding and IL-2-mediated lymphocyte activation, a critical cellular immune response pathway. |
|
ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1569 |
|
Accepted_Therapeutic_Use_For |
Kidney transplant rejection, prevention |
|
ALT_DEFINITION |
A monoclonal antibody that is being studied in the treatment of adult T-cell leukemia and in the treatment of cytopenia (low blood cell count). |
|
CAS_Registry |
152923-56-3 |
|
code |
C1569 |
|
Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
Contributing_Source |
CTRP FDA GDC |
|
DEFINITION |
A recombinant monoclonal antibody interleukin-2 receptor antagonist. Daclizumab binds specifically to the alpha subunit of the human interleukin-2 (IL-2) receptor expressed on the surface of activated lymphocytes in vivo, thereby inhibiting IL-2 binding and IL-2-mediated lymphocyte activation, a critical cellular immune response pathway. |
|
Display_Name |
Daclizumab |
|
FDA_UNII_Code |
CUJ2MVI71Y |
|
FULL_SYN |
Anti-Tac Monoclonal Antibody Monoclonal Antibody Anti-Tac Anti-Tac Humanized Monoclonal Antibody Humanized Anti-Tac Monoclonal Antibody Anti-Tac DACLIZUMAB Dacliximab Daclizumab Zenapax daclizumab |
|
Has_Target | ||
Is_Value_For_GDC_Property | ||
label |
Daclizumab |
|
Legacy Concept Name |
Daclizumab |
|
Maps_To |
Daclizumab |
|
NCI_Drug_Dictionary_ID |
42006 |
|
NSC Number |
725173 |
|
PDQ_Closed_Trial_Search_ID |
42006 |
|
PDQ_Open_Trial_Search_ID |
42006 |
|
Preferred_Name |
Daclizumab |
|
prefixIRI |
Thesaurus:C1569 |
|
Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance Immunologic Factor |
|
UMLS_CUI |
C0663182 |
|
subClassOf |