National Cancer Institute Thesaurus

Last uploaded: July 29, 2019
Preferred Name

Penicillin Antibiotic

Synonyms

penicillin

Penicillin Antibiotic

Definitions

Any beta-lactam antibiotic derived from Pencillium fungi with bactericidal activity. Penicillin antibiotics bind to and inactivate penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall, eventually causing cell lysis.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1500

ALT_DEFINITION

A drug that is used to treat infection. It belongs to the family of drugs called antibiotics.

CHEBI_ID

CHEBI:17334

code

C1500

DEFINITION

Any beta-lactam antibiotic derived from Pencillium fungi with bactericidal activity. Penicillin antibiotics bind to and inactivate penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall, eventually causing cell lysis.

FULL_SYN

penicillin

Penicillin Antibiotic

label

Penicillin Antibiotic

Legacy_Concept_Name

Penicillin_Antibiotic

Preferred_Name

Penicillin Antibiotic

prefixIRI

ncit:C1500

Semantic_Type

Organic Chemical

Antibiotic

UMLS_CUI

C0030842

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C260

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