loading...| Preferred Name |
Rifabutin |
|
| Synonyms |
LM-427 Mycobutin RIFABUTIN Rifabutin rifabutin |
|
| Definitions |
A semisynthetic ansamycin antibiotic with potent antimycobacterial properties. Rifabutin inhibits bacterial DNA-dependent RNA polymerase, thereby suppressing the initiation of RNA formation and leading to inhibition of RNA synthesis and transcription. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1408 |
|
| Accepted_Therapeutic_Use_For |
Prevention and treatment of Mycobacterium avium complex (MAC) and tuberculosis in patients with HIV infection |
|
| ALT_DEFINITION |
A drug used to prevent the spread of a bacterium called in patients with advanced HIV (the virus that causes AIDS) infection. It blocks an enzyme that the bacteria need to grow. It is a type of antibiotic. |
|
| CAS_Registry |
72559-06-9 |
|
| CHEBI_ID |
CHEBI:45367 |
|
| Chemical_Formula |
C46H62N4O11 |
|
| code |
C1408 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
A semisynthetic ansamycin antibiotic with potent antimycobacterial properties. Rifabutin inhibits bacterial DNA-dependent RNA polymerase, thereby suppressing the initiation of RNA formation and leading to inhibition of RNA synthesis and transcription. (NCI04) |
|
| FDA_UNII_Code |
1W306TDA6S |
|
| FULL_SYN |
LM-427 Mycobutin RIFABUTIN Rifabutin rifabutin |
|
| label |
Rifabutin |
|
| Legacy Concept Name |
Rifabutin |
|
| NCI_Drug_Dictionary_ID |
37812 |
|
| PDQ_Closed_Trial_Search_ID |
37812 |
|
| PDQ_Open_Trial_Search_ID |
37812 |
|
| Preferred_Name |
Rifabutin |
|
| prefixIRI |
Thesaurus:C1408 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance Antibiotic |
|
| UMLS_CUI |
C0140575 |
|
| subClassOf |