loading...| Preferred Name |
Lithium Carbonate |
| Synonyms |
Eskalith Lithobid Escalith Lithium carbonate Lithotabs Lithium Lithane Lithium Carbonate LITHIUM CARBONATE Lithonate |
| Definitions |
The carbonate salt of lithium, a soft alkali metal, with antimanic and hematopoietic activities. Lithium interferes with transmembrane sodium exchange in nerve cells by affecting sodium, potassium-stimulated adenosine triphosphatase (Na+, K+-ATPase); alters the release of neurotransmitters; affects cyclic adenosine monophosphate (cAMP) concentrations; and blocks inositol metabolism resulting in depletion of cellular inositol and inhibition of phospholipase C-mediated signal transduction. The exact mechanism through which lithium exerts its mood-stabilizing effect has not been established. In addition, lithium stimulates granulocytopoiesis and appears to increase the level of pluripotent hematopoietic stem cells by stimulating the release of hematopoietic cytokines and/or directly acting on hematopoietic stem cells. |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1318 |
| CAS_Registry |
554-13-2 |
| CHEBI_ID |
CHEBI:6504 |
| Chemical_Formula |
CO3.2Li |
| code |
C1318 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 |
| Contributing_Source |
CTRP FDA |
| DEFINITION |
The carbonate salt of lithium, a soft alkali metal, with antimanic and hematopoietic activities. Lithium interferes with transmembrane sodium exchange in nerve cells by affecting sodium, potassium-stimulated adenosine triphosphatase (Na+, K+-ATPase); alters the release of neurotransmitters; affects cyclic adenosine monophosphate (cAMP) concentrations; and blocks inositol metabolism resulting in depletion of cellular inositol and inhibition of phospholipase C-mediated signal transduction. The exact mechanism through which lithium exerts its mood-stabilizing effect has not been established. In addition, lithium stimulates granulocytopoiesis and appears to increase the level of pluripotent hematopoietic stem cells by stimulating the release of hematopoietic cytokines and/or directly acting on hematopoietic stem cells. |
| Display_Name |
Lithium Carbonate |
| FDA_UNII_Code |
2BMD2GNA4V |
| FULL_SYN |
Eskalith Lithobid Escalith Lithium carbonate Lithotabs Lithium Lithane Lithium Carbonate LITHIUM CARBONATE Lithonate |
| label |
Lithium Carbonate |
| Legacy_Concept_Name |
Lithium_Carbonate |
| NSC_Code |
16895 |
| PDQ_Closed_Trial_Search_ID |
39491 |
| PDQ_Open_Trial_Search_ID |
39491 |
| Preferred_Name |
Lithium Carbonate |
| prefixIRI |
ncit:C1318 |
| Semantic_Type |
Pharmacologic Substance Inorganic Chemical |
| UMLS_CUI |
C0085217 |
| subClassOf |