National Cancer Institute Thesaurus

Last uploaded: March 26, 2019
Preferred Name

Lithium Carbonate

Synonyms

Eskalith

Lithobid

Escalith

Lithium carbonate

Lithotabs

Lithium

Lithane

Lithium Carbonate

LITHIUM CARBONATE

Lithonate

Definitions

The carbonate salt of lithium, a soft alkali metal, with antimanic and hematopoietic activities. Lithium interferes with transmembrane sodium exchange in nerve cells by affecting sodium, potassium-stimulated adenosine triphosphatase (Na+, K+-ATPase); alters the release of neurotransmitters; affects cyclic adenosine monophosphate (cAMP) concentrations; and blocks inositol metabolism resulting in depletion of cellular inositol and inhibition of phospholipase C-mediated signal transduction. The exact mechanism through which lithium exerts its mood-stabilizing effect has not been established. In addition, lithium stimulates granulocytopoiesis and appears to increase the level of pluripotent hematopoietic stem cells by stimulating the release of hematopoietic cytokines and/or directly acting on hematopoietic stem cells.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1318

CAS_Registry

554-13-2

CHEBI_ID

CHEBI:6504

Chemical_Formula

CO3.2Li

code

C1318

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

The carbonate salt of lithium, a soft alkali metal, with antimanic and hematopoietic activities. Lithium interferes with transmembrane sodium exchange in nerve cells by affecting sodium, potassium-stimulated adenosine triphosphatase (Na+, K+-ATPase); alters the release of neurotransmitters; affects cyclic adenosine monophosphate (cAMP) concentrations; and blocks inositol metabolism resulting in depletion of cellular inositol and inhibition of phospholipase C-mediated signal transduction. The exact mechanism through which lithium exerts its mood-stabilizing effect has not been established. In addition, lithium stimulates granulocytopoiesis and appears to increase the level of pluripotent hematopoietic stem cells by stimulating the release of hematopoietic cytokines and/or directly acting on hematopoietic stem cells.

Display_Name

Lithium Carbonate

FDA_UNII_Code

2BMD2GNA4V

FULL_SYN

Eskalith

Lithobid

Escalith

Lithium carbonate

Lithotabs

Lithium

Lithane

Lithium Carbonate

LITHIUM CARBONATE

Lithonate

label

Lithium Carbonate

Legacy_Concept_Name

Lithium_Carbonate

NSC_Code

16895

PDQ_Closed_Trial_Search_ID

39491

PDQ_Open_Trial_Search_ID

39491

Preferred_Name

Lithium Carbonate

prefixIRI

ncit:C1318

Semantic_Type

Pharmacologic Substance

Inorganic Chemical

UMLS_CUI

C0085217

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29710

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http://purl.bioontology.org/ontology/SNMI/C-63C11 SNMI LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387095003 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/VANDF/4018007 VANDF LOOM
http://purl.bioontology.org/ontology/RCD/d61.. RCD LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D01.200.275.150.550 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDDF/001533 NDDF LOOM
http://purl.bioontology.org/ontology/RXNORM/42351 RXNORM LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146351 NDFRT LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Lithium_Carbonate APAONTO LOOM
http://purl.bioontology.org/ontology/MESH/D016651 MESH LOOM
http://purl.obolibrary.org/obo/CHEBI_6504 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_6504 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_6504 NBO LOOM
http://purl.obolibrary.org/obo/CHEBI_6504 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_6504 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_6504 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_6504 CHEBI LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004050 FASTO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004050 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004050 DMTO LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/16977003 SNOMEDCT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D016651 RH-MESH LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000039491 PDQ LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D01.510.475 RH-MESH LOOM
http://www.co-ode.org/ontologies/galen#LithiumCarbonate GALEN LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D01.045.125.500 RH-MESH LOOM