Preferred Name |
Olsalazine |
|
Synonyms |
3,3'-Dicarboxy-4,4'-dihydroxyazobenzene C.I. Mordant Yellow 5 Azodisalicylate 3,3'-Azobis[6-hydroxybenzoic Acid] OLSALAZINE Olsalazine |
|
Definitions |
A prodrug of mesalamine (5-Aminosalicylic acid; 5-ASA) with anti-inflammatory activity. Unabsorbed olsalazine passes through gastrointestinal tract and is cleaved by azoreductases, produced by microflora in colon, into 2 active molecules of 5-ASA. 5-ASA exerts its anti-inflammatory action locally by inhibiting cyclooxygenase and lipoxygenase activities, thereby reducing the production of prostaglandins and leukotrienes. In addition, mesalamine may act as a scavenger of reactive oxygen free radicals. |
|
ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1176 |
|
Accepted_Therapeutic_Use_For |
Ulcerative colitis |
|
CAS_Registry |
15722-48-2 |
|
CHEBI_ID |
CHEBI:7770 |
|
Chemical_Formula |
C14H10N2O6 |
|
code |
C1176 |
|
Concept_In_Subset | ||
Contributing_Source |
FDA |
|
DEFINITION |
A prodrug of mesalamine (5-Aminosalicylic acid; 5-ASA) with anti-inflammatory activity. Unabsorbed olsalazine passes through gastrointestinal tract and is cleaved by azoreductases, produced by microflora in colon, into 2 active molecules of 5-ASA. 5-ASA exerts its anti-inflammatory action locally by inhibiting cyclooxygenase and lipoxygenase activities, thereby reducing the production of prostaglandins and leukotrienes. In addition, mesalamine may act as a scavenger of reactive oxygen free radicals. |
|
FDA_UNII_Code |
ULS5I8J03O |
|
FULL_SYN |
3,3'-Dicarboxy-4,4'-dihydroxyazobenzene C.I. Mordant Yellow 5 Azodisalicylate 3,3'-Azobis[6-hydroxybenzoic Acid] OLSALAZINE Olsalazine |
|
Has_Salt_Form | ||
label |
Olsalazine |
|
Legacy Concept Name |
Olsalazine |
|
NCI_Drug_Dictionary_ID |
41828 |
|
PDQ_Closed_Trial_Search_ID |
41828 |
|
PDQ_Open_Trial_Search_ID |
41828 |
|
Preferred_Name |
Olsalazine |
|
prefixIRI |
Thesaurus:C1176 |
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Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
UMLS_CUI |
C0069454 |
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subClassOf |