loading...| Preferred Name |
Decitabine |
|
| Synonyms |
2'-Deoxy-5-azacytidine 5-Aza-2'-deoxycytidine 5-Aza-2'deoxycytidine 5-Azadeoxycytidine Decitabine for Injection Deoxyazacytidine 4-Amino-1-(2-deoxy-beta-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one Dezocitidine 5-Aza-2-deoxycytidine DECITABINE Dacogen Decitabine decitabine |
|
| Definitions |
A cytidine antimetabolite analogue with potential antineoplastic activity. Decitabine incorporates into DNA and inhibits DNA methyltransferase, resulting in hypomethylation of DNA and intra-S-phase arrest of DNA replication. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C981 |
|
| Accepted_Therapeutic_Use_For |
Myelodysplastic Syndrome |
|
| ALT_DEFINITION |
A drug that is used to treat myelodysplastic syndromes and is being studied in the treatment of other types of cancer. It is a type of antimetabolite. |
|
| CAS_Registry |
2353-33-5 |
|
| CHEBI_ID |
CHEBI:50131 |
|
| Chemical_Formula |
C8H12N4O4 |
|
| code |
C981 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
CTRP FDA GDC HemOnc |
|
| DEFINITION |
A cytidine antimetabolite analogue with potential antineoplastic activity. Decitabine incorporates into DNA and inhibits DNA methyltransferase, resulting in hypomethylation of DNA and intra-S-phase arrest of DNA replication. (NCI04) |
|
| Display_Name |
Decitabine |
|
| FDA_UNII_Code |
776B62CQ27 |
|
| FULL_SYN |
2'-Deoxy-5-azacytidine 5-Aza-2'-deoxycytidine 5-Aza-2'deoxycytidine 5-Azadeoxycytidine Decitabine for Injection Deoxyazacytidine 4-Amino-1-(2-deoxy-beta-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one Dezocitidine 5-Aza-2-deoxycytidine DECITABINE Dacogen Decitabine decitabine |
|
| Has_Target | ||
| Is_Value_For_GDC_Property | ||
| label |
Decitabine |
|
| Legacy Concept Name |
Decitabine |
|
| Maps_To |
Decitabine |
|
| NCI_Drug_Dictionary_ID |
39299 |
|
| NSC Number |
127716 |
|
| PDQ_Closed_Trial_Search_ID |
39299 |
|
| PDQ_Open_Trial_Search_ID |
39299 |
|
| Preferred_Name |
Decitabine |
|
| prefixIRI |
Thesaurus:C981 |
|
| Semantic_Type |
Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide |
|
| UMLS_CUI |
C0049065 |
|
| subClassOf |