National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Preferred Name

Lucitanib
Synonyms

1-Naphthalenecarboxamide, 6-((7-((1-aminocyclopropyl)methoxy)-6-methoxy-4-quinolinyl)oxy)-n-methyl-

AL3810

E-3810

LUCITANIB

Lucitanib
Definitions

A novel dual inhibitor targeting human vascular endothelial growth factor receptors (VEGFRs) and fibroblast growth factor receptors (FGFRs) with antiangiogenic activity. Lucitanib inhibits VEGFR-1, -2, -3 and FGFR-1, -2 kinases in the nM range, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death. Both VEGFRs and FGFRs belong to the family of receptor tyrosine kinases that may be upregulated in various tumor cell types.
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C95726
CAS_Registry

1058137-23-7
code

C95726
Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537
Contributing_Source

FDA

GDC
DEFINITION

A novel dual inhibitor targeting human vascular endothelial growth factor receptors (VEGFRs) and fibroblast growth factor receptors (FGFRs) with antiangiogenic activity. Lucitanib inhibits VEGFR-1, -2, -3 and FGFR-1, -2 kinases in the nM range, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death. Both VEGFRs and FGFRs belong to the family of receptor tyrosine kinases that may be upregulated in various tumor cell types.
FDA_UNII_Code

PP449XA4BH
FULL_SYN

1-Naphthalenecarboxamide, 6-((7-((1-aminocyclopropyl)methoxy)-6-methoxy-4-quinolinyl)oxy)-n-methyl-

AL3810

E-3810

LUCITANIB

Lucitanib
Is_Value_For_GDC_Property

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1909
label

Lucitanib
Maps_To

Lucitanib
NCI_Drug_Dictionary_ID

694590
PDQ_Closed_Trial_Search_ID

694590
PDQ_Open_Trial_Search_ID

694590
Preferred_Name

Lucitanib
prefixIRI

Thesaurus:C95726
Semantic_Type

Pharmacologic Substance
UMLS_CUI

C3887575
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C93259
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