loading...| Preferred Name |
Trimethoprim-Sulfamethoxazole |
|
| Synonyms |
Trimethoprim/Sulfamethoxazole (Bactrim DS) Cotrimoxazole Co-Trimoxazole Trimethoprim/Sulfamethoxazole Trimethoprim-Sulfamethoxazole Sulfamethoprim co-trimoxazole trimethoprim-sulfamethoxazole Bactrim Bactrim DS Bactrimel Centran Centrin Cotrim Eslectin Insozalin SMZ-TMP Septra Sulfatrim Sulmeprim TMP-SMX Trimedin Trimezole Uroplus |
|
| Definitions |
A synthetic combination of two antibacterial agents, trimethoprim and sulfamethoxazole. This synergistic combination, also known as Co-Trimoxazole, inhibits two sequential steps in the bacterial metabolism of folic acid. Trimethoprim is a pyrimidine inhibitor of dihydrofolate reductase; sulfamethoxazole is a sulfamide inhibitor of bacterial dihydrofolate synthase. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C909 |
|
| Accepted_Therapeutic_Use_For |
Pneumocystis carinii pneumonia; Various bacterial infections |
|
| ALT_DEFINITION |
An antibiotic drug used to treat infection and prevent pneumocystis carinii pneumonia. |
|
| CAS_Registry |
8064-90-2 |
|
| CHEBI_ID |
CHEBI:3770 |
|
| code |
C909 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
| Contributing_Source |
CTRP HemOnc |
|
| DEFINITION |
A synthetic combination of two antibacterial agents, trimethoprim and sulfamethoxazole. This synergistic combination, also known as Co-Trimoxazole, inhibits two sequential steps in the bacterial metabolism of folic acid. Trimethoprim is a pyrimidine inhibitor of dihydrofolate reductase; sulfamethoxazole is a sulfamide inhibitor of bacterial dihydrofolate synthase. |
|
| Display_Name |
Trimethoprim-Sulfamethoxazole |
|
| FULL_SYN |
Trimethoprim/Sulfamethoxazole (Bactrim DS) Cotrimoxazole Co-Trimoxazole Trimethoprim/Sulfamethoxazole Trimethoprim-Sulfamethoxazole Sulfamethoprim co-trimoxazole trimethoprim-sulfamethoxazole Bactrim Bactrim DS Bactrimel Centran Centrin Cotrim Eslectin Insozalin SMZ-TMP Septra Sulfatrim Sulmeprim TMP-SMX Trimedin Trimezole Uroplus |
|
| label |
Trimethoprim-Sulfamethoxazole |
|
| Legacy Concept Name |
Trimethoprim-Sulfamethoxazole |
|
| NCI_Drug_Dictionary_ID |
39724 |
|
| NSC Number |
618652 |
|
| PDQ_Closed_Trial_Search_ID |
39724 |
|
| PDQ_Open_Trial_Search_ID |
39724 |
|
| Preferred_Name |
Trimethoprim-Sulfamethoxazole |
|
| prefixIRI |
Thesaurus:C909 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0041044 |
|
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://purl.bioontology.org/ontology/PDQ/CDR0000039724 | PDQ | LOOM | |
| http://purl.bioontology.org/ontology/LNC/LP16302-9 | LOINC | LOOM | |
| http://purl.obolibrary.org/obo/NCIT_C909 | BERO | LOOM | |
| http://purl.bioontology.org/ontology/LNC/MTHU008494 | LOINC | LOOM | |
| http://purl.obolibrary.org/obo/ARO_3004024 | ARO | LOOM |