National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Tiotropium Bromide

Synonyms

Tiotropium Bromide

TIOTROPIUM BROMIDE ANHYDROUS

Definitions

The bromide salt form of tiotropium, a quaternary ammonium derivative of atropine and a muscarinic receptor antagonist, with bronchodilating activity. Although it does not display selectivity for specific muscarinic receptors, on topical application, tiotropium bromide acts mainly on M3 muscarinic receptors located on smooth muscle cells and submucosal glands, preventing smooth muscle contraction and mucus secretion, thus producing a bronchodilatory effect.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C84608

CAS_Registry

136310-93-5

Chemical_Formula

C19H22NO4S2.Br

code

C84608

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

The bromide salt form of tiotropium, a quaternary ammonium derivative of atropine and a muscarinic receptor antagonist, with bronchodilating activity. Although it does not display selectivity for specific muscarinic receptors, on topical application, tiotropium bromide acts mainly on M3 muscarinic receptors located on smooth muscle cells and submucosal glands, preventing smooth muscle contraction and mucus secretion, thus producing a bronchodilatory effect.

FDA_UNII_Code

XX112XZP0J

FULL_SYN

Tiotropium Bromide

TIOTROPIUM BROMIDE ANHYDROUS

Has_Free_Acid_Or_Base_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C76004

label

Tiotropium Bromide

NCI_META_CUI

CL449040

Preferred_Name

Tiotropium Bromide

prefixIRI

Thesaurus:C84608

Semantic_Type

Pharmacologic Substance

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29704

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