loading...| Preferred Name |
Cannabinol |
|
| Synonyms |
6,6,9-Trimethyl-3-pentyl-6H-dibenzo(b,d)pyran-1-ol 3-Amyl-1-hydroxy-6,6,9-trimethyl-6H-dibenzo(b,d)pyran CANNABINOL CBN Cannabinol |
|
| Definitions |
A cannabinoid isolated from the plant Cannabis that is a metabolite of tetrahydrocannabinol (THC), with potential immunosuppressive and anti-inflammatory activities. Cannabinol preferentially binds to the cannabinoid G-protein coupled receptor CB2, which is mainly expressed on a variety of immune cells, such as T-cells, B-cells, macrophages and dendritic cells. Stimulation of CB2 receptors by cannabinol may both trigger apoptosis in these cells and inhibit the production of a variety of cytokines. Cannabinol exerts minimal affinity for CB1 and has a weak effect on the central nervous system. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C84510 |
|
| CAS_Registry |
521-35-7 |
|
| Chemical_Formula |
C21H26O2 |
|
| code |
C84510 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
A cannabinoid isolated from the plant Cannabis that is a metabolite of tetrahydrocannabinol (THC), with potential immunosuppressive and anti-inflammatory activities. Cannabinol preferentially binds to the cannabinoid G-protein coupled receptor CB2, which is mainly expressed on a variety of immune cells, such as T-cells, B-cells, macrophages and dendritic cells. Stimulation of CB2 receptors by cannabinol may both trigger apoptosis in these cells and inhibit the production of a variety of cytokines. Cannabinol exerts minimal affinity for CB1 and has a weak effect on the central nervous system. |
|
| FDA_UNII_Code |
7UYP6MC9GH |
|
| FULL_SYN |
6,6,9-Trimethyl-3-pentyl-6H-dibenzo(b,d)pyran-1-ol 3-Amyl-1-hydroxy-6,6,9-trimethyl-6H-dibenzo(b,d)pyran CANNABINOL CBN Cannabinol |
|
| label |
Cannabinol |
|
| NCI_Drug_Dictionary_ID |
750101 |
|
| NSC Number |
134455 |
|
| PDQ_Closed_Trial_Search_ID |
750101 |
|
| PDQ_Open_Trial_Search_ID |
750101 |
|
| Preferred_Name |
Cannabinol |
|
| prefixIRI |
Thesaurus:C84510 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C0006865 |
|
| subClassOf |