loading...| Preferred Name |
Streptonigrin |
|
| Synonyms |
Bruneomycin STREPTONIGRIN 5-Amino-6-(70-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolyl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methylpicolinic Acid Rufocromomycin Streptonigrin 5-Amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolyl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methyl-2-pyridinecarboxylic Acid BA-163 PC-501 STN |
|
| Definitions |
An aminoquinone antineoplastic antibiotic isolated from the bacterium Streptomyces flocculus. Streptonigrin complexes with DNA and topoisomerase II, resulting in DNA cleavage and inhibition of DNA replication and RNA synthesis. This agent also acts as a reverse transcriptase inhibitor and causes free radical-mediated cellular damage. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C844 |
|
| CAS_Registry |
3930-19-6 |
|
| CHEBI_ID |
CHEBI:9287 |
|
| Chemical_Formula |
C25H22N4O8 |
|
| code |
C844 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
FDA GDC |
|
| DEFINITION |
An aminoquinone antineoplastic antibiotic isolated from the bacterium Streptomyces flocculus. Streptonigrin complexes with DNA and topoisomerase II, resulting in DNA cleavage and inhibition of DNA replication and RNA synthesis. This agent also acts as a reverse transcriptase inhibitor and causes free radical-mediated cellular damage. (NCI04) |
|
| FDA_UNII_Code |
261Q3JB310 |
|
| FULL_SYN |
Bruneomycin STREPTONIGRIN 5-Amino-6-(70-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolyl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methylpicolinic Acid Rufocromomycin Streptonigrin 5-Amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolyl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methyl-2-pyridinecarboxylic Acid BA-163 PC-501 STN |
|
| Is_Value_For_GDC_Property | ||
| label |
Streptonigrin |
|
| Legacy Concept Name |
Streptonigrin |
|
| Maps_To |
Streptonigrin |
|
| NCI_Drug_Dictionary_ID |
39703 |
|
| NSC Number |
45383 83950 |
|
| PDQ_Closed_Trial_Search_ID |
39703 |
|
| PDQ_Open_Trial_Search_ID |
39703 |
|
| Preferred_Name |
Streptonigrin |
|
| prefixIRI |
Thesaurus:C844 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance Antibiotic |
|
| UMLS_CUI |
C0038427 |
|
| subClassOf |