National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Fenfluramine

Synonyms

1-(meta-Trifluoromethyl-phenyl)-2 Ethylaminopropane

2-Ethylamino-1-(3-trifluoromethylphenyl)propane

FENFLURAMINE

Fenfluramine

3-(Trifluoromethyl)-N-ethyl-alpha-methylphenethylamine

Definitions

An amphetamine derivative and a sympathomimetic stimulant with appetite-suppressant property. Fenfluramine, which was part of the Fen-Phen anti-obesity medication, stimulates the release of serotonin from vesicular storage, and modulates serotonin transporter function. Since serotonin regulates mood and appetite, among other functions, increased serotonin level results in a feeling of fullness and loss of appetite.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C81418

CAS_Registry

458-24-2

CHEBI_ID

CHEBI:5000

Chemical_Formula

C12H16F3N

code

C81418

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

An amphetamine derivative and a sympathomimetic stimulant with appetite-suppressant property. Fenfluramine, which was part of the Fen-Phen anti-obesity medication, stimulates the release of serotonin from vesicular storage, and modulates serotonin transporter function. Since serotonin regulates mood and appetite, among other functions, increased serotonin level results in a feeling of fullness and loss of appetite.

FDA_UNII_Code

2DS058H2CF

FULL_SYN

1-(meta-Trifluoromethyl-phenyl)-2 Ethylaminopropane

2-Ethylamino-1-(3-trifluoromethylphenyl)propane

FENFLURAMINE

Fenfluramine

3-(Trifluoromethyl)-N-ethyl-alpha-methylphenethylamine

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C75112

label

Fenfluramine

Legacy Concept Name

Fenfluramine

Preferred_Name

Fenfluramine

prefixIRI

Thesaurus:C81418

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0015827

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29728

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Delete Mapping To Ontology Source
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Fenfluramine APAONTO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#4963 OCHV LOOM
http://purl.obolibrary.org/obo/CHEBI_5000 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_5000 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_5000 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_5000 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_5000 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_5000 DRON LOOM
http://purl.bioontology.org/ontology/RXNORM/4328 RXNORM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.092.471.683.467 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDDF/004776 NDDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D005277 RH-MESH LOOM
http://purl.bioontology.org/ontology/ATC/A08AA02 ATC LOOM
http://purl.obolibrary.org/obo/OMIT_0006495 OMIT LOOM
http://www.drugbank.ca/drugs/DB00574 FTC LOOM
https://go.drugbank.com/drugs/DB00574 MDM LOOM
http://purl.bioontology.org/ontology/ATC/N03AX26 ATC LOOM
http://purl.bioontology.org/ontology/MESH/D005277 MESH LOOM
http://bmi.utah.edu/ontologies/hfontology/C0015827 HFO LOOM
http://purl.bioontology.org/ontology/VANDF/4019754 VANDF LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387451002 SNOMEDCT LOOM
http://www.phoc.org.cn/pmo/class/PMO_00016170 PMAPP-PMO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0015827 OCHV LOOM
http://purl.obolibrary.org/obo/NCIT_C81418 BERO LOOM
http://www.case.edu/EpilepsyOntology.owl#Fenfluramine EPSO LOOM
http://purl.bioontology.org/ontology/LNC/MTHU016791 LOINC LOOM
http://purl.bioontology.org/ontology/RCD/x01Bw RCD LOOM
http://purl.bioontology.org/ontology/SNMI/C-65040 SNMI LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147845 NDFRT LOOM
http://purl.bioontology.org/ontology/CSP/2268-6789 CRISP LOOM
http://purl.bioontology.org/ontology/LNC/LP16145-2 LOINC LOOM
http://purl.obolibrary.org/obo/MESH_D005277 BERO LOOM