loading...| Preferred Name |
Rabeprazole Sodium |
|
| Synonyms |
LY 307640 Sodium Rabeprazole Sodium 2-(((4-(3-Methoxypropoxy)-3-methyl-2-pyridyl)methyl)sulfinyl)benzimidazole Sodium Salt RABEPRAZOLE SODIUM Aciphex E-3810 Pariet Rablet |
|
| Definitions |
The sodium salt of the prodrug rabeprazole, a substituted benzimidazole proton pump inhibitor, with potential anti-ulcer activity. After protonation, accumulation, and transformation to the active sulfenamide within the acidic environment of gastric parietal cells, rabeprazole selectively and irreversibly binds to and inhibits the H+, K+ATPase (hydrogen-potassium adenosine triphosphatase) enzyme system located on the parietal cell secretory surface, inhibiting gastric acid secretion. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C80692 |
|
| CAS_Registry |
117976-90-6 |
|
| CHEBI_ID |
CHEBI:8769 |
|
| Chemical_Formula |
C18H20N3O3S.Na |
|
| code |
C80692 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
The sodium salt of the prodrug rabeprazole, a substituted benzimidazole proton pump inhibitor, with potential anti-ulcer activity. After protonation, accumulation, and transformation to the active sulfenamide within the acidic environment of gastric parietal cells, rabeprazole selectively and irreversibly binds to and inhibits the H+, K+ATPase (hydrogen-potassium adenosine triphosphatase) enzyme system located on the parietal cell secretory surface, inhibiting gastric acid secretion. |
|
| FDA_UNII_Code |
3L36P16U4R |
|
| FULL_SYN |
LY 307640 Sodium Rabeprazole Sodium 2-(((4-(3-Methoxypropoxy)-3-methyl-2-pyridyl)methyl)sulfinyl)benzimidazole Sodium Salt RABEPRAZOLE SODIUM Aciphex E-3810 Pariet Rablet |
|
| Has_Free_Acid_Or_Base_Form | ||
| label |
Rabeprazole Sodium |
|
| Legacy Concept Name |
Rabeprazole_Sodium |
|
| NCI_Drug_Dictionary_ID |
641009 |
|
| PDQ_Closed_Trial_Search_ID |
641009 |
|
| PDQ_Open_Trial_Search_ID |
641009 |
|
| Preferred_Name |
Rabeprazole Sodium |
|
| prefixIRI |
Thesaurus:C80692 |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0732569 |
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| subClassOf |