loading...| Preferred Name |
Prochlorperazine Maleate |
|
| Synonyms |
Prochlorperazine Maleate PROCHLORPERAZINE MALEATE Prochlorperazine Dimaleate Compazine |
|
| Definitions |
The maleate salt form of prochlorperazine, a synthetic, piperazine phenothiazine derivative with antiemetic, antipsychotic, antihistaminic, and anticholinergic activities. Prochlorperazine binds to and blocks the postsynaptic dopamine D2-receptor in the chemoreceptor trigger zone (CTZ) of the brain and may prevent chemotherapy-induced emesis. Prochlorperazine maleate also blocks anticholinergic and alpha-adrenergic receptors. Its antagonistic actions on the alpha-1 adrenergic receptors results in sedation, muscle relaxation, and hypotension. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C775 |
|
| CAS_Registry |
84-02-6 |
|
| CHEBI_ID |
CHEBI:8436 |
|
| Chemical_Formula |
C20H24ClN3S.2C4H4O4 |
|
| code |
C775 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
The maleate salt form of prochlorperazine, a synthetic, piperazine phenothiazine derivative with antiemetic, antipsychotic, antihistaminic, and anticholinergic activities. Prochlorperazine binds to and blocks the postsynaptic dopamine D2-receptor in the chemoreceptor trigger zone (CTZ) of the brain and may prevent chemotherapy-induced emesis. Prochlorperazine maleate also blocks anticholinergic and alpha-adrenergic receptors. Its antagonistic actions on the alpha-1 adrenergic receptors results in sedation, muscle relaxation, and hypotension. |
|
| FDA_UNII_Code |
I1T8O1JTL6 |
|
| FULL_SYN |
Prochlorperazine Maleate PROCHLORPERAZINE MALEATE Prochlorperazine Dimaleate Compazine |
|
| Has_Free_Acid_Or_Base_Form | ||
| label |
Prochlorperazine Maleate |
|
| Legacy Concept Name |
Prochlorperazine_Maleate |
|
| NCI_Drug_Dictionary_ID |
39564 |
|
| NSC Number |
17478 |
|
| PDQ_Closed_Trial_Search_ID |
39564 |
|
| PDQ_Open_Trial_Search_ID |
39564 |
|
| Preferred_Name |
Prochlorperazine Maleate |
|
| prefixIRI |
Thesaurus:C775 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0033231 |
|
| subClassOf |