National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Jump to:
loading...
Preferred Name

Testosterone Gel
Synonyms

Testosterone Gel

AndroGel

Fortesta
Definitions

A topical gel preparation of synthetic testosterone. In vivo, testosterone is irreversibly converted to dihydrotestosterone (DHT) in target tissues by the enzyme 5-alpha reductase. Testosterone or DHT ligand-androgen receptor complexes act as transcription factor complexes, stimulating the expression of various responsive genes, resulting in an increase in protein anabolism, a decrease in amino acid catabolism, and retention of nitrogen, potassium, and phosphorus; DHT binds with higher affinity to nuclear androgen receptors than testosterone. In addition, testosterone is irreversibly converted to estradiol by the enzyme complex aromatase, particularly in the liver and adipose tissue. Testosterone and DHT promote the development and maintenance of male sex characteristics related to the internal and external genitalia, skeletal muscle, and hair follicles; estradiol promotes epiphyseal maturation and bone mineralization.
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C74081
Accepted_Therapeutic_Use_For

Hypogonadism -- Male
code

C74081
Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977
Contributing_Source

CTRP
DEFINITION

A topical gel preparation of synthetic testosterone. In vivo, testosterone is irreversibly converted to dihydrotestosterone (DHT) in target tissues by the enzyme 5-alpha reductase. Testosterone or DHT ligand-androgen receptor complexes act as transcription factor complexes, stimulating the expression of various responsive genes, resulting in an increase in protein anabolism, a decrease in amino acid catabolism, and retention of nitrogen, potassium, and phosphorus; DHT binds with higher affinity to nuclear androgen receptors than testosterone. In addition, testosterone is irreversibly converted to estradiol by the enzyme complex aromatase, particularly in the liver and adipose tissue. Testosterone and DHT promote the development and maintenance of male sex characteristics related to the internal and external genitalia, skeletal muscle, and hair follicles; estradiol promotes epiphyseal maturation and bone mineralization.
Display_Name

Testosterone Gel
FULL_SYN

Testosterone Gel

AndroGel

Fortesta
Has_Target

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17063
label

Testosterone Gel
Legacy Concept Name

Testosterone_Gel
NCI_Drug_Dictionary_ID

589197
PDQ_Closed_Trial_Search_ID

589197
PDQ_Open_Trial_Search_ID

589197
Preferred_Name

Testosterone Gel
prefixIRI

Thesaurus:C74081
Semantic_Type

Pharmacologic Substance
UMLS_CUI

C0875960
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C862
Add comment
Add proposal
Delete Subject Author Type Created
No notes to display