loading...| Preferred Name |
Bendamustine |
|
| Synonyms |
Bendamustine bendamustine BENDAMUSTINE 5-(Bis(2-chloroethyl)amino)-1-methyl-2-benzimidazolebutyric Acid SDX-105 |
|
| Definitions |
A bifunctional mechlorethamine derivative with alkylating and antimetabolite activities. Although the exact mechanism of action of bendamustine is unknown, this agent appears to alkylate and crosslink macromolecules, resulting in DNA, RNA and protein synthesis inhibition, and eventually the induction of apoptosis. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C73261 |
|
| Accepted_Therapeutic_Use_For |
Chronic Lymphocytic Leukemia, Indolent B-cell non-Hodgkin Lymphoma |
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| ALT_DEFINITION |
The active ingredient in a drug that is used to treat chronic lymphocytic leukemia (CLL), to treat slow-growing B-cell non-Hodgkin lymphoma (NHL) that has gotten worse within 6 months of treatment with other anticancer drugs, and is being studied in the treatment of other types of cancer. Bendamustine may damage the DNA in cancer cells and cause them to die. It is a type of alkylating agent and a type of antimetabolite. |
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| CAS_Registry |
16506-27-7 |
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| Chemical_Formula |
C16H21Cl2N3O2 |
|
| code |
C73261 |
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186328 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186327 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186341 |
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| Contributing_Source |
FDA GDC HemOnc PCDC |
|
| DEFINITION |
A bifunctional mechlorethamine derivative with alkylating and antimetabolite activities. Although the exact mechanism of action of bendamustine is unknown, this agent appears to alkylate and crosslink macromolecules, resulting in DNA, RNA and protein synthesis inhibition, and eventually the induction of apoptosis. |
|
| FDA_UNII_Code |
9266D9P3PQ |
|
| FULL_SYN |
Bendamustine bendamustine BENDAMUSTINE 5-(Bis(2-chloroethyl)amino)-1-methyl-2-benzimidazolebutyric Acid SDX-105 |
|
| Has_Salt_Form | ||
| Is_Value_For_GDC_Property | ||
| label |
Bendamustine |
|
| Legacy Concept Name |
Bendamustine |
|
| Maps_To |
Bendamustine |
|
| Preferred_Name |
Bendamustine |
|
| prefixIRI |
Thesaurus:C73261 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C0525079 |
|
| subClassOf |