loading...| Preferred Name |
Norethindrone Acetate |
|
| Synonyms |
Norethindrone acetate NORETHINDRONE ACETATE Ortho Micronor Norethindrone Acetate Norethisterone Acetate Norethisterone acetate Aygestin Nor-Q.D. Norlutate |
|
| Definitions |
The orally bioavailable acetate salt of norethindrone, a synthetic progestin with some anabolic, estrogenic, and androgenic activities. As do all progestins, norethindrone binds to and activates nuclear progesterone receptors (PRs) in target tissues such as the pituitary and reproductive system; ligand-receptor complexes are translocated to the nucleus where they bind to progesterone response elements (PREs) located on target genes, followed by various transcriptional events and histone acetylation. Physiological effects include the inhibition of luteinizing hormone (LH) release, an increase in the endometrial luteal-phase, and alterations in endocervical mucus secretion. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C702 |
|
| CAS_Registry |
51-98-9 |
|
| Chemical_Formula |
C22H28O3 |
|
| code |
C702 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
The orally bioavailable acetate salt of norethindrone, a synthetic progestin with some anabolic, estrogenic, and androgenic activities. As do all progestins, norethindrone binds to and activates nuclear progesterone receptors (PRs) in target tissues such as the pituitary and reproductive system; ligand-receptor complexes are translocated to the nucleus where they bind to progesterone response elements (PREs) located on target genes, followed by various transcriptional events and histone acetylation. Physiological effects include the inhibition of luteinizing hormone (LH) release, an increase in the endometrial luteal-phase, and alterations in endocervical mucus secretion. |
|
| FDA_UNII_Code |
9S44LIC7OJ |
|
| FULL_SYN |
Norethindrone acetate NORETHINDRONE ACETATE Ortho Micronor Norethindrone Acetate Norethisterone Acetate Norethisterone acetate Aygestin Nor-Q.D. Norlutate |
|
| Has_Free_Acid_Or_Base_Form | ||
| label |
Norethindrone Acetate |
|
| Legacy Concept Name |
Norethindrone |
|
| NCI_Drug_Dictionary_ID |
39254 |
|
| NSC Number |
9564 |
|
| PDQ_Closed_Trial_Search_ID |
39254 |
|
| PDQ_Open_Trial_Search_ID |
39254 |
|
| Preferred_Name |
Norethindrone Acetate |
|
| prefixIRI |
Thesaurus:C702 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0699165 |
|
| subClassOf |