loading...| Preferred Name |
Pasireotide |
|
| Synonyms |
Pasireotide PASIREOTIDE Cyclo((4R)-4-(2-aminoethylcarbamoyloxy)-L-prolyl-L-phenylglycyl-D-tryptophyl-L-lysyl-4-O-benzyl-L-tyrosyl-L-phenylalanyl-) SOM230 |
|
| Definitions |
A synthetic long-acting cyclic peptide with somatostatin-like activity. Pasireotide activates a broad spectrum of somatostatin receptors, exhibiting a much higher binding affinity for somatostatin receptors 1, 3, and 5 than octreotide in vitro, as well as a comparable binding affinity for somatostatin receptor 2. This agent is more potent than somatostatin in inhibiting the release of human growth hormone (HGH), glucagon, and insulin. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C69131 |
|
| CAS_Registry |
396091-73-9 |
|
| Chemical_Formula |
C58H66N10O9 |
|
| code |
C69131 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 |
|
| Contributing_Source |
CTRP FDA GDC |
|
| DEFINITION |
A synthetic long-acting cyclic peptide with somatostatin-like activity. Pasireotide activates a broad spectrum of somatostatin receptors, exhibiting a much higher binding affinity for somatostatin receptors 1, 3, and 5 than octreotide in vitro, as well as a comparable binding affinity for somatostatin receptor 2. This agent is more potent than somatostatin in inhibiting the release of human growth hormone (HGH), glucagon, and insulin. |
|
| Display_Name |
Pasireotide |
|
| FDA_UNII_Code |
98H1T17066 |
|
| FULL_SYN |
Pasireotide PASIREOTIDE Cyclo((4R)-4-(2-aminoethylcarbamoyloxy)-L-prolyl-L-phenylglycyl-D-tryptophyl-L-lysyl-4-O-benzyl-L-tyrosyl-L-phenylalanyl-) SOM230 |
|
| Has_Target | ||
| Is_Value_For_GDC_Property | ||
| label |
Pasireotide |
|
| Legacy Concept Name |
Pasireotide |
|
| Maps_To |
Pasireotide |
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| NCI_Drug_Dictionary_ID |
540440 |
|
| PDQ_Closed_Trial_Search_ID |
540440 |
|
| PDQ_Open_Trial_Search_ID |
540440 |
|
| Preferred_Name |
Pasireotide |
|
| prefixIRI |
Thesaurus:C69131 |
|
| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance |
|
| UMLS_CUI |
C1872203 |
|
| subClassOf |