loading...| Preferred Name |
Cabazitaxel |
|
| Synonyms |
CABAZITAXEL taxoid XRP6258 Cabazitaxel Taxoid XRP6258 cabazitaxel RPR-116258A 1-hydroxy-7beta,10beta-dimethoxy-9-oxo-5beta,20-epoxytax-11-ene-2alpha,4,13alpha-triyl 4-acetate 2-benzoate 13-[(2R,3S)-3-{[(tertbutoxy)carbonyl]amino}-2-hydroxy-3-phenylpropanoate] Jevtana RPR116258A TXD258 XRP-6258 XRP6258 |
|
| Definitions |
A semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel binds to and stabilizes tubulin, resulting in the inhibition of microtubule depolymerization and cell division, cell cycle arrest in the G2/M phase, and the inhibition of tumor cell proliferation. Unlike other taxane compounds, this agent is a poor substrate for the membrane-associated, multidrug resistance (MDR), P-glycoprotein (P-gp) efflux pump and may be useful for treating multidrug-resistant tumors. In addition, cabazitaxel penetrates the blood-brain barrier (BBB). |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66937 |
|
| Accepted_Therapeutic_Use_For |
metastatic hormone-refractory prostate cancer |
|
| ALT_DEFINITION |
A drug used with prednisone to treat hormone-resistant prostate cancer that has spread and that had been treated with docetaxel. It is also being studied in the treatment of other types of cancer. Cabazitaxel blocks cell growth by stopping cell division and may kill cancer cells. It is a type of antimitotic agent. |
|
| CAS_Registry |
183133-96-2 |
|
| CHEBI_ID |
CHEBI:63584 |
|
| Chemical_Formula |
C45H57NO14 |
|
| code |
C66937 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192234 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
CTRP FDA GDC HemOnc OORO |
|
| DEFINITION |
A semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel binds to and stabilizes tubulin, resulting in the inhibition of microtubule depolymerization and cell division, cell cycle arrest in the G2/M phase, and the inhibition of tumor cell proliferation. Unlike other taxane compounds, this agent is a poor substrate for the membrane-associated, multidrug resistance (MDR), P-glycoprotein (P-gp) efflux pump and may be useful for treating multidrug-resistant tumors. In addition, cabazitaxel penetrates the blood-brain barrier (BBB). |
|
| Display_Name |
Cabazitaxel |
|
| FDA_UNII_Code |
51F690397J |
|
| FULL_SYN |
CABAZITAXEL taxoid XRP6258 Cabazitaxel Taxoid XRP6258 cabazitaxel RPR-116258A 1-hydroxy-7beta,10beta-dimethoxy-9-oxo-5beta,20-epoxytax-11-ene-2alpha,4,13alpha-triyl 4-acetate 2-benzoate 13-[(2R,3S)-3-{[(tertbutoxy)carbonyl]amino}-2-hydroxy-3-phenylpropanoate] Jevtana RPR116258A TXD258 XRP-6258 XRP6258 |
|
| Has_Target | ||
| Is_Value_For_GDC_Property | ||
| label |
Cabazitaxel |
|
| Legacy Concept Name |
XRP6258 |
|
| Maps_To |
Cabazitaxel |
|
| NCI_Drug_Dictionary_ID |
534131 |
|
| PDQ_Closed_Trial_Search_ID |
534131 |
|
| PDQ_Open_Trial_Search_ID |
534131 |
|
| Preferred_Name |
Cabazitaxel |
|
| prefixIRI |
Thesaurus:C66937 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C2830183 |
|
| subClassOf |