loading...| Preferred Name |
Amifostine Anhydrous |
|
| Synonyms |
Ethiofos Anhydrous Amifostine Anhydrous S-(2-((3-Aminopropyl)amino)ethyl) Dihydrogen Phosphorothioate AMIFOSTINE ANHYDROUS Amifostine YM-08310 amifostine |
|
| Definitions |
A phosphorylated aminosulfhydryl compound with cytoprotective activity. Amifostine is dephosphorylated by alkaline phosphatase to an active free sulfhydryl (thiol) metabolite in the body. The thiol metabolite binds to and detoxifies cytotoxic platinum-containing metabolites of cisplatin and scavenges free radicals induced by cisplatin and ionizing radiation. The elevated activity of this agent in normal tissues results from both the relative abundance of alkaline phosphatase in normal tissues and the greater vascularity of normal tissues compared to tumor tissues. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66724 |
|
| ALT_DEFINITION |
A drug used as a chemoprotective drug to control some of the side effects of chemotherapy and radiation therapy. |
|
| CAS_Registry |
20537-88-6 |
|
| CHEBI_ID |
CHEBI:2636 |
|
| Chemical_Formula |
C5H15N2O3PS |
|
| code |
C66724 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
A phosphorylated aminosulfhydryl compound with cytoprotective activity. Amifostine is dephosphorylated by alkaline phosphatase to an active free sulfhydryl (thiol) metabolite in the body. The thiol metabolite binds to and detoxifies cytotoxic platinum-containing metabolites of cisplatin and scavenges free radicals induced by cisplatin and ionizing radiation. The elevated activity of this agent in normal tissues results from both the relative abundance of alkaline phosphatase in normal tissues and the greater vascularity of normal tissues compared to tumor tissues. |
|
| FDA_UNII_Code |
ILA426L95O |
|
| FULL_SYN |
Ethiofos Anhydrous Amifostine Anhydrous S-(2-((3-Aminopropyl)amino)ethyl) Dihydrogen Phosphorothioate AMIFOSTINE ANHYDROUS Amifostine YM-08310 amifostine |
|
| label |
Amifostine Anhydrous |
|
| Legacy Concept Name |
Amifostine_Base |
|
| Preferred_Name |
Amifostine Anhydrous |
|
| prefixIRI |
Thesaurus:C66724 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C3537278 |
|
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://purl.obolibrary.org/obo/NCIT_C66724 | BERO | LOOM | |
| http://purl.bioontology.org/ontology/RXNORM/1545987 | RXNORM | LOOM |