loading...| Preferred Name |
Mitotane |
|
| Synonyms |
Ethane, 2-(o-chlorophenyl)-2-(p-chlorophenyl)-1,1-dichloro- 1,1-Dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane 2, 4'-Dichlorodiphenyldichloroethane Ortho,para-DDD 1-Chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]benzene 2, 2-Bis(2-chlorophenyl-4-chlorophenyl)-1,1-dichloroethane 1, 1-Dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane 2,2-Bis(2-chlorophenyl-4-chlorophenyl)-1,1-dichloroethane 2-(2-Chlorophenyl)-2-(4-chlorophenyl)-1,1-dichloroethane Chlodithane 2,4'-Dichlorodiphenyldichloroethane (o,p)-DDD CB 313 CB-313 Chloditan DDD Khloditan Lisodren Lysodren MITOTANE Mitotane Mytotan WR-13045 mitotane o,p' - DDD o,p'-DDD |
|
| Definitions |
A synthetic derivative of the insecticide dichlorodiphenyl trichloroethane (DDT) with anti-adrenocorticoid properties. Following its metabolism in the adrenal cortex to a reactive acyl chloride intermediate, mitotane covalently binds to adrenal proteins, specifically inhibiting adrenal cortical hormone production. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C664 |
|
| Accepted_Therapeutic_Use_For |
Adrenocortical carcinoma |
|
| ALT_DEFINITION |
An anticancer drug used in treating adrenocortical cancer and ACTH-producing pituitary tumors (Cushing's disease). |
|
| CAS_Registry |
53-19-0 |
|
| Chemical_Formula |
C14H10Cl4 |
|
| code |
C664 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
CTRP FDA GDC HemOnc |
|
| DEFINITION |
A synthetic derivative of the insecticide dichlorodiphenyl trichloroethane (DDT) with anti-adrenocorticoid properties. Following its metabolism in the adrenal cortex to a reactive acyl chloride intermediate, mitotane covalently binds to adrenal proteins, specifically inhibiting adrenal cortical hormone production. (NCI04) |
|
| Display_Name |
Mitotane |
|
| FDA_UNII_Code |
78E4J5IB5J |
|
| FULL_SYN |
Ethane, 2-(o-chlorophenyl)-2-(p-chlorophenyl)-1,1-dichloro- 1,1-Dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane 2, 4'-Dichlorodiphenyldichloroethane Ortho,para-DDD 1-Chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]benzene 2, 2-Bis(2-chlorophenyl-4-chlorophenyl)-1,1-dichloroethane 1, 1-Dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane 2,2-Bis(2-chlorophenyl-4-chlorophenyl)-1,1-dichloroethane 2-(2-Chlorophenyl)-2-(4-chlorophenyl)-1,1-dichloroethane Chlodithane 2,4'-Dichlorodiphenyldichloroethane (o,p)-DDD CB 313 CB-313 Chloditan DDD Khloditan Lisodren Lysodren MITOTANE Mitotane Mytotan WR-13045 mitotane o,p' - DDD o,p'-DDD |
|
| Is_Value_For_GDC_Property | ||
| label |
Mitotane |
|
| Legacy Concept Name |
Mitotane |
|
| Maps_To |
Mitotane |
|
| NCI_Drug_Dictionary_ID |
39506 |
|
| NSC Number |
38721 |
|
| PDQ_Closed_Trial_Search_ID |
39506 |
|
| PDQ_Open_Trial_Search_ID |
39506 |
|
| Preferred_Name |
Mitotane |
|
| prefixIRI |
Thesaurus:C664 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0026256 |
|
| subClassOf |