Preferred Name |
Phenprocoumon |
|
Synonyms |
3-(alpha-Phenylpropyl)-4-hydroxycoumarin PHENPROCOUMON Phenprocoumon 2H-1-Benzopyran-2-one, 4-Hydroxy-3-(1-phenylpropyl)- Liquamar |
|
Definitions |
An orally available, long-acting derivative of coumarin with anticoagulant activity. Upon administration, phenprocoumon inhibits the vitamin K epoxide reductase enzyme; inhibition of this enzyme prevents the formation of the reduced, active form of vitamin K (vitamin KH2), which is essential for the carboxylation of glutamate residues of vitamin K-dependent proteins. This prevents the activation of vitamin K-dependent coagulation factors II, VII, IX, and X and the anticoagulant proteins C and S, which abrogates both thrombin production and thrombus formation. |
|
ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66374 |
|
CAS_Registry |
435-97-2 |
|
CHEBI_ID |
CHEBI:50438 |
|
Chemical_Formula |
C18H16O3 |
|
code |
C66374 |
|
Concept_In_Subset | ||
Contributing_Source |
FDA |
|
DEFINITION |
An orally available, long-acting derivative of coumarin with anticoagulant activity. Upon administration, phenprocoumon inhibits the vitamin K epoxide reductase enzyme; inhibition of this enzyme prevents the formation of the reduced, active form of vitamin K (vitamin KH2), which is essential for the carboxylation of glutamate residues of vitamin K-dependent proteins. This prevents the activation of vitamin K-dependent coagulation factors II, VII, IX, and X and the anticoagulant proteins C and S, which abrogates both thrombin production and thrombus formation. |
|
FDA_UNII_Code |
Q08SIO485D |
|
FULL_SYN |
3-(alpha-Phenylpropyl)-4-hydroxycoumarin PHENPROCOUMON Phenprocoumon 2H-1-Benzopyran-2-one, 4-Hydroxy-3-(1-phenylpropyl)- Liquamar |
|
label |
Phenprocoumon |
|
Legacy Concept Name |
Phenprocoumon |
|
NCI_Drug_Dictionary_ID |
750561 |
|
PDQ_Closed_Trial_Search_ID |
750561 |
|
PDQ_Open_Trial_Search_ID |
750561 |
|
Preferred_Name |
Phenprocoumon |
|
prefixIRI |
Thesaurus:C66374 |
|
Semantic_Type |
Pharmacologic Substance |
|
UMLS_CUI |
C0031444 |
|
subClassOf |