National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Levomepromazine

Synonyms

Methotrimeprazine

(-)-10-(3-(Dimethylamino)-2-methylpropyl)-2-methoxyphenothiazine

Levomepromazine

LEVOMEPROMAZINE

Arc-VI-C-5

Bayer 1213

Levoprome

Neozine

Nirvan

Nozinan

Definitions

A phenothiazine and typical antipsychotic agent, with sedative/hypnotic, anxiolytic, antiemetic, analgesic and antipsychotic activities. Although the exact mechanism of action of levomepromazine is not fully known, upon administration, this agent appears to act as an antagonist for a variety of receptors in the central nervous system (CNS), including adrenergic, dopamine, histamine, cholinergic and serotonin (5-hydroxytryptamine; 5-HT) receptors. Blocking these receptors results in levomepromazine's pharmacologic effects.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66118

CAS_Registry

60-99-1

CHEBI_ID

CHEBI:6838

Chemical_Formula

C19H24N2OS

code

C66118

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A phenothiazine and typical antipsychotic agent, with sedative/hypnotic, anxiolytic, antiemetic, analgesic and antipsychotic activities. Although the exact mechanism of action of levomepromazine is not fully known, upon administration, this agent appears to act as an antagonist for a variety of receptors in the central nervous system (CNS), including adrenergic, dopamine, histamine, cholinergic and serotonin (5-hydroxytryptamine; 5-HT) receptors. Blocking these receptors results in levomepromazine's pharmacologic effects.

FDA_UNII_Code

9G0LAW7ATQ

FULL_SYN

Methotrimeprazine

(-)-10-(3-(Dimethylamino)-2-methylpropyl)-2-methoxyphenothiazine

Levomepromazine

LEVOMEPROMAZINE

Arc-VI-C-5

Bayer 1213

Levoprome

Neozine

Nirvan

Nozinan

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C78109

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66009

label

Levomepromazine

Legacy Concept Name

Methotrimeprazine

Preferred_Name

Levomepromazine

prefixIRI

Thesaurus:C66118

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0025678

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C740

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