loading...| Preferred Name |
Esomeprazole Sodium |
|
| Synonyms |
1H-Benzimidazole, 6-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2- pyridinyl)methyl]sulfinyl]-, Sodium Salt (1:1) Esomeprazole Sodium ESOMEPRAZOLE SODIUM |
|
| Definitions |
The sodium salt of the S-isomer of omeprazole, with gastric proton pump inhibitor activity. In the acidic compartment of parietal cells, esomeprazole is protonated and converted into the active achiral sulfenamide; the active sulfenamide forms one or more covalent disulfide bonds with the proton pump hydrogen-potassium adenosine triphosphatase (H+/K+ ATPase), thereby inhibiting its activity and the parietal cell secretion of H+ ions into the gastric lumen, the final step in gastric acid production. H+/K+ ATPase is an integral membrane protein of the gastric parietal cell. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C65539 |
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| CAS_Registry |
161796-78-7 |
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| Chemical_Formula |
C17H18N3O3S.Na |
|
| code |
C65539 |
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| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
The sodium salt of the S-isomer of omeprazole, with gastric proton pump inhibitor activity. In the acidic compartment of parietal cells, esomeprazole is protonated and converted into the active achiral sulfenamide; the active sulfenamide forms one or more covalent disulfide bonds with the proton pump hydrogen-potassium adenosine triphosphatase (H+/K+ ATPase), thereby inhibiting its activity and the parietal cell secretion of H+ ions into the gastric lumen, the final step in gastric acid production. H+/K+ ATPase is an integral membrane protein of the gastric parietal cell. |
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| FDA_UNII_Code |
L2C9GWQ43H |
|
| FULL_SYN |
1H-Benzimidazole, 6-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2- pyridinyl)methyl]sulfinyl]-, Sodium Salt (1:1) Esomeprazole Sodium ESOMEPRAZOLE SODIUM |
|
| Has_Free_Acid_Or_Base_Form | ||
| label |
Esomeprazole Sodium |
|
| Legacy Concept Name |
Esomeprazole_Sodium |
|
| Preferred_Name |
Esomeprazole Sodium |
|
| prefixIRI |
Thesaurus:C65539 |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C1337241 |
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| subClassOf |