National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Azlocillin Sodium

Synonyms

Azlocillin Sodium

AZLOCILLIN SODIUM

Definitions

The sodium salt form of azlocillin, a semisynthetic, extended spectrum acylampicillin with antibacterial activity. Azlocillin binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, thereby inhibiting the cross-linkage of peptidoglycans, which are critical components of the bacterial cell wall. This prevents proper bacterial cell wall synthesis, thereby results in the weakening of the bacterial cell wall and eventually leading to cell lysis.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C65243

CAS_Registry

37091-65-9

CHEBI_ID

CHEBI:51864

Chemical_Formula

C20H22N5O6S.Na

code

C65243

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

The sodium salt form of azlocillin, a semisynthetic, extended spectrum acylampicillin with antibacterial activity. Azlocillin binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, thereby inhibiting the cross-linkage of peptidoglycans, which are critical components of the bacterial cell wall. This prevents proper bacterial cell wall synthesis, thereby results in the weakening of the bacterial cell wall and eventually leading to cell lysis.

FDA_UNII_Code

DWV1EFW947

FULL_SYN

Azlocillin Sodium

AZLOCILLIN SODIUM

Has_Free_Acid_Or_Base_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C293

label

Azlocillin Sodium

Legacy Concept Name

Azlocillin_Sodium

Preferred_Name

Azlocillin Sodium

prefixIRI

Thesaurus:C65243

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0701436

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1500

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