loading...| Preferred Name |
Labetalol Hydrochloride |
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| Synonyms |
Labetalol Hydrochloride LABETALOL HYDROCHLORIDE Normodyne Trandate |
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| Definitions |
The hydrochloride form of labetalol, a third generation selective alpha-1-adrenergic antagonist and non-selective beta-adrenergic antagonist with vasodilatory and antihypertensive properties. Labetalol competitively binds to alpha-1-adrenergic receptors in vascular smooth muscle, thereby inhibiting the adrenergic stimulation of endothelial cell function and vasoconstriction in peripheral blood vessels. This agent also binds to beta-receptors in the bronchial and vascular smooth muscle, resulting in a decrease in adrenergic stimulation. The result is a decrease in resting and exercise heart rates, cardiac output, and in both systolic and diastolic blood pressure, thereby resulting in vasodilation, and negative chronotropic and inotropic cardiac effects. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63578 |
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| CAS_Registry |
32780-64-6 |
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| Chemical_Formula |
C19H24N2O3.HCl |
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| code |
C63578 |
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| Concept_In_Subset | ||
| Contributing_Source |
FDA |
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| DEFINITION |
The hydrochloride form of labetalol, a third generation selective alpha-1-adrenergic antagonist and non-selective beta-adrenergic antagonist with vasodilatory and antihypertensive properties. Labetalol competitively binds to alpha-1-adrenergic receptors in vascular smooth muscle, thereby inhibiting the adrenergic stimulation of endothelial cell function and vasoconstriction in peripheral blood vessels. This agent also binds to beta-receptors in the bronchial and vascular smooth muscle, resulting in a decrease in adrenergic stimulation. The result is a decrease in resting and exercise heart rates, cardiac output, and in both systolic and diastolic blood pressure, thereby resulting in vasodilation, and negative chronotropic and inotropic cardiac effects. |
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| FDA_UNII_Code |
1GEV3BAW9J |
|
| FULL_SYN |
Labetalol Hydrochloride LABETALOL HYDROCHLORIDE Normodyne Trandate |
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| Has_Free_Acid_Or_Base_Form | ||
| label |
Labetalol Hydrochloride |
|
| Legacy Concept Name |
Labetalol_Hydrochloride |
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| NSC Number |
290312 |
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| Preferred_Name |
Labetalol Hydrochloride |
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| prefixIRI |
Thesaurus:C63578 |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0699440 |
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| subClassOf |