loading...| Preferred Name |
Phenoxybenzamine |
|
| Synonyms |
Phenoxybenzamine N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-benzenemethanamine PHENOXYBENZAMINE |
|
| Definitions |
A synthetic, dibenzamine alpha adrenergic antagonist with antihypertensive and vasodilatory properties. Phenoxybenzamine non-selectively and irreversibly blocks the postsynaptic alpha-adrenergic receptor in smooth muscle, thereby preventing vasoconstriction, relieving vasospasms, and decreasing peripheral resistance. Reflex tachycardia may occur and may be enhanced by blockade of alpha-2 receptors which enhances norepinephrine release. Phenoxybenzamine is reasonably anticipated to be a human carcinogen. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62065 |
|
| CAS_Registry |
59-96-1 |
|
| Chemical_Formula |
C18H22ClNO |
|
| code |
C62065 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
A synthetic, dibenzamine alpha adrenergic antagonist with antihypertensive and vasodilatory properties. Phenoxybenzamine non-selectively and irreversibly blocks the postsynaptic alpha-adrenergic receptor in smooth muscle, thereby preventing vasoconstriction, relieving vasospasms, and decreasing peripheral resistance. Reflex tachycardia may occur and may be enhanced by blockade of alpha-2 receptors which enhances norepinephrine release. Phenoxybenzamine is reasonably anticipated to be a human carcinogen. |
|
| FDA_UNII_Code |
0TTZ664R7Z |
|
| FULL_SYN |
Phenoxybenzamine N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-benzenemethanamine PHENOXYBENZAMINE |
|
| Has_Salt_Form | ||
| label |
Phenoxybenzamine |
|
| Legacy Concept Name |
Phenoxybenzamine_Base |
|
| Preferred_Name |
Phenoxybenzamine |
|
| prefixIRI |
Thesaurus:C62065 |
|
| Semantic_Type |
Pharmacologic Substance Hazardous or Poisonous Substance |
|
| UMLS_CUI |
C0031441 |
|
| subClassOf |