National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Preferred Name

Tiotropium Bromide Monohydrate
Synonyms

Tiotropium Bromide Monohydrate

1,4-Dihydro-3,5-Diiodo-1-Methyl-4-Oxopyridine-2,6-Dicarboxylic Acid

TIOTROPIUM BROMIDE MONOHYDRATE

6Beta,7Beta-Epoxy-3Beta-Hydroxy-8-Methyl-1Alpha-H,5Alpha-H-Tropanium Bromide, Di-2-Thienylglycolate Monohydrate

Spiriva
Definitions

The monohydrate bromide salt form of tiotropium, a quaternary ammonium derivative of atropine and a long-acting muscarinic receptor antagonist, with bronchodilating activity. Upon inhalation, tiotropium binds to and blocks mainly muscarinic M3 receptors located on smooth muscle cells, thereby preventing smooth muscle contraction.
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61974
CAS_Registry

411207-31-3
Chemical_Formula

C19H22NO4S2.Br.H2O
code

C61974
Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923
Contributing_Source

FDA
DEFINITION

The monohydrate bromide salt form of tiotropium, a quaternary ammonium derivative of atropine and a long-acting muscarinic receptor antagonist, with bronchodilating activity. Upon inhalation, tiotropium binds to and blocks mainly muscarinic M3 receptors located on smooth muscle cells, thereby preventing smooth muscle contraction.
FDA_UNII_Code

L64SXO195N
FULL_SYN

Tiotropium Bromide Monohydrate

1,4-Dihydro-3,5-Diiodo-1-Methyl-4-Oxopyridine-2,6-Dicarboxylic Acid

TIOTROPIUM BROMIDE MONOHYDRATE

6Beta,7Beta-Epoxy-3Beta-Hydroxy-8-Methyl-1Alpha-H,5Alpha-H-Tropanium Bromide, Di-2-Thienylglycolate Monohydrate

Spiriva
Has_Free_Acid_Or_Base_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C76004
label

Tiotropium Bromide Monohydrate
Legacy Concept Name

Tiotropium_Bromide_Monohydrate
NCI_Drug_Dictionary_ID

682857
PDQ_Closed_Trial_Search_ID

682857
PDQ_Open_Trial_Search_ID

682857
Preferred_Name

Tiotropium Bromide Monohydrate
prefixIRI

Thesaurus:C61974
Semantic_Type

Pharmacologic Substance
UMLS_CUI

C0905678
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29704
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