National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Imipramine Pamoate

Synonyms

IMIPRAMINE PAMOATE

Imipramine Pamoate

Tofranil-PM

Definitions

The pamoate salt of imipramine, a synthetic dibenzazepine derivative with anti-depressant activity. Imipramine pamoate, a tricyclic antidepressant (TCA) potentiates the activity of adrenergic synapses by blocking the re-uptake of norepinephrine and serotonin, thereby preventing their degradation and increasing their availability. This drug also has antimuscarinic and anti-histamine properties, which contribute to its side effects.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61788

CAS_Registry

10075-24-8

22540-17-6

Chemical_Formula

C23H16O6.2C19H24N2

code

C61788

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

The pamoate salt of imipramine, a synthetic dibenzazepine derivative with anti-depressant activity. Imipramine pamoate, a tricyclic antidepressant (TCA) potentiates the activity of adrenergic synapses by blocking the re-uptake of norepinephrine and serotonin, thereby preventing their degradation and increasing their availability. This drug also has antimuscarinic and anti-histamine properties, which contribute to its side effects.

FDA_UNII_Code

MC34P30298

FULL_SYN

IMIPRAMINE PAMOATE

Imipramine Pamoate

Tofranil-PM

Has_Free_Acid_Or_Base_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62039

label

Imipramine Pamoate

Legacy Concept Name

Imipramine_Pamoate

Preferred_Name

Imipramine Pamoate

prefixIRI

Thesaurus:C61788

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0304368

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C94727

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