loading...| Preferred Name |
Epiandrosterone |
|
| Synonyms |
EPIANDROSTERONE Epiandrosterone |
|
| Definitions |
A dehydroepiandrosterone metabolite and a precursor of testosterone and estradiol with hypolipidemic and anabolic property. Epiandrosterone, a potential neurosteroid, appears to bind to the gamma-aminobutyric acid (GABA)/benzodiazepine-receptor complex (GABA-RC), acting as a negative non-competitive modulator of GABA-RC as well as signal through the N-methyl-D-aspartate receptor. In addition this agent inhibits the pentose phosphate pathway (PPP) thereby dilating blood vessels pre-contracted by partial depolarization. Also, epiandrosterone inhibits the synthesis of thromboxane A2 in activated platelets, reduces plasma plasminogen activator inhibitor type 1 and tissue plasminogen activator antigen, increases serum levels of insulin-like growth factor 1 and increases cyclic guanosine monophosphate and nitric oxide synthesis. These effects may improve circulation in the microvasculature. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61747 |
|
| CAS_Registry |
481-29-8 |
|
| CHEBI_ID |
CHEBI:541975 |
|
| Chemical_Formula |
C19H30O2 |
|
| code |
C61747 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
A dehydroepiandrosterone metabolite and a precursor of testosterone and estradiol with hypolipidemic and anabolic property. Epiandrosterone, a potential neurosteroid, appears to bind to the gamma-aminobutyric acid (GABA)/benzodiazepine-receptor complex (GABA-RC), acting as a negative non-competitive modulator of GABA-RC as well as signal through the N-methyl-D-aspartate receptor. In addition this agent inhibits the pentose phosphate pathway (PPP) thereby dilating blood vessels pre-contracted by partial depolarization. Also, epiandrosterone inhibits the synthesis of thromboxane A2 in activated platelets, reduces plasma plasminogen activator inhibitor type 1 and tissue plasminogen activator antigen, increases serum levels of insulin-like growth factor 1 and increases cyclic guanosine monophosphate and nitric oxide synthesis. These effects may improve circulation in the microvasculature. |
|
| FDA_UNII_Code |
8TR252Z538 |
|
| FULL_SYN |
EPIANDROSTERONE Epiandrosterone |
|
| label |
Epiandrosterone |
|
| Legacy Concept Name |
Epiandrosterone |
|
| Preferred_Name |
Epiandrosterone |
|
| prefixIRI |
Thesaurus:C61747 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C0014483 |
|
| subClassOf |