loading...| Preferred Name |
Diindolylmethane |
|
| Synonyms |
diindolylmethane 3,3'-Methylenebis-1H-indole Di-Indoly Methane Diindolylmethane 3,3'-Diindolymethane 3,3'-DIINDOLYLMETHANE CCRIS 5806 DIM DIM-Plus DIMPRO |
|
| Definitions |
A phytonutrient and plant indole found in cruciferous vegetables including broccoli, Brussels sprouts, cabbage, cauliflower and kale, with potential anti-androgenic and antineoplastic activities. As a dimer of indole-3-carbinol, diindolylmethane (DIM) promotes beneficial estrogen metabolism in both sexes by reducing the levels of 16-hydroxy estrogen metabolites and increasing the formation of 2-hydroxy estrogen metabolites, resulting in increased antioxidant activity. Although this agent induces apoptosis in tumor cells in vitro, the exact mechanism by which DIM exhibits its antineoplastic activity in vivo is unknown. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C53434 |
|
| ALT_DEFINITION |
A substance being studied in the treatment of prostate cancer and in the prevention of cervical cancer. Diindolylmethane is found in cruciferous vegetables like broccoli, brussels sprouts, cauliflower, cabbage, and kale. It is a type of plant indole. |
|
| CAS_Registry |
1968-05-4 |
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| CHEBI_ID |
CHEBI:50182 |
|
| code |
C53434 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
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| Contributing_Source |
CTRP FDA GDC |
|
| DEFINITION |
A phytonutrient and plant indole found in cruciferous vegetables including broccoli, Brussels sprouts, cabbage, cauliflower and kale, with potential anti-androgenic and antineoplastic activities. As a dimer of indole-3-carbinol, diindolylmethane (DIM) promotes beneficial estrogen metabolism in both sexes by reducing the levels of 16-hydroxy estrogen metabolites and increasing the formation of 2-hydroxy estrogen metabolites, resulting in increased antioxidant activity. Although this agent induces apoptosis in tumor cells in vitro, the exact mechanism by which DIM exhibits its antineoplastic activity in vivo is unknown. |
|
| Display_Name |
Diindolylmethane |
|
| FDA_UNII_Code |
SSZ9HQT61Z |
|
| FULL_SYN |
diindolylmethane 3,3'-Methylenebis-1H-indole Di-Indoly Methane Diindolylmethane 3,3'-Diindolymethane 3,3'-DIINDOLYLMETHANE CCRIS 5806 DIM DIM-Plus DIMPRO |
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| Is_Value_For_GDC_Property | ||
| label |
Diindolylmethane |
|
| Legacy Concept Name |
Diindolylmethane |
|
| Maps_To |
Diindolylmethane |
|
| NCI_Drug_Dictionary_ID |
462587 |
|
| PDQ_Closed_Trial_Search_ID |
462587 |
|
| PDQ_Open_Trial_Search_ID |
462587 |
|
| Preferred_Name |
Diindolylmethane |
|
| prefixIRI |
Thesaurus:C53434 |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C1100708 |
|
| subClassOf |