National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Thiamine Hydrochloride

Synonyms

Thiamine Hydrochloride

Vitamin B1 Hydrochloride

THIAMINE HYDROCHLORIDE

3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-m-ethylthiazolium Chloride, Monohydrochloride

Definitions

The hydrochloride salt form of thiamine, a vitamin essential for aerobic metabolism, cell growth, transmission of nerve impulses and acetylcholine synthesis. Upon hydrolysis, thiamine hydrochloride is phosphorylated by thiamine diphosphokinase to form active thiamine pyrophosphate (TPP), also known as cocarboxylase. TPP is a coenzyme for many enzymatic activities involving fatty acid, amino acid and carbohydrate metabolism.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C48025

CAS_Registry

67-03-8

CHEBI_ID

CHEBI:49105

Chemical_Formula

C12H17N4OS.Cl.HCl

code

C48025

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

The hydrochloride salt form of thiamine, a vitamin essential for aerobic metabolism, cell growth, transmission of nerve impulses and acetylcholine synthesis. Upon hydrolysis, thiamine hydrochloride is phosphorylated by thiamine diphosphokinase to form active thiamine pyrophosphate (TPP), also known as cocarboxylase. TPP is a coenzyme for many enzymatic activities involving fatty acid, amino acid and carbohydrate metabolism.

FDA_UNII_Code

M572600E5P

FULL_SYN

Thiamine Hydrochloride

Vitamin B1 Hydrochloride

THIAMINE HYDROCHLORIDE

3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-m-ethylthiazolium Chloride, Monohydrochloride

Has_Free_Acid_Or_Base_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C874

label

Thiamine Hydrochloride

Legacy Concept Name

Thiamine_Hydrochloride

NSC Number

36226

Preferred_Name

Thiamine Hydrochloride

prefixIRI

Thesaurus:C48025

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0770309

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26017

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